Pressure overload hypertrophic cardiomyopathy (PO-HCM), a prevalent cardiovascular condition, is characterized by the heart's adaptive response to chronic pressure overload. However, excessive pressure overload contributes to cardiomyocyte dysfunction and pathological hypertrophy. The pathological hallmarks of PO-HCM include the abnormal enlargement of cardiomyocytes (hypertrophy) and structural remodeling of myocardial tissue. The pathogenesis is multifaceted and involves hemodynamic alterations, imbalances in neurohumoral regulation, and intracellular signaling pathway abnormalities. Within this pathological context, programmed cell death is critically involved in cardiomyocytes. This review synthesizes current research on programmed cell death mechanisms in PO-HCM-including apoptosis, necroptosis, pyroptosis, autophagy, and ferroptosis-to inform translational research and guide future therapeutic development.
基金：
the National Natural Science Foundation of China (No. 82160157), the Joint Funds of
the National Natural Science Foundation of China (No. U20A2018),
and the Natural Science Foundation of Beijing (Nos. 7242046 and
7222044).
第一作者机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Dept Anesthesiol, Beijing 100029, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Dept Anesthesiol, Beijing 100029, Peoples R China[5]Linzhi Peoples Hosp, Linzhi 860099, Tibet, Peoples R China
推荐引用方式(GB/T 7714)：
Xiao Fei,Li Hui-Li,Wang Jia-Rui,et al.Research progress on programmed cell death of cardiomyocytes in pressure-overload hypertrophic cardiomyopathy[J].APOPTOSIS.2025,30(9-10):2191-2224.doi:10.1007/s10495-025-02146-5.
APA：
Xiao, Fei,Li, Hui-Li,Wang, Jia-Rui,Wu, Hui-Min,Cai, Yu-Qi...&Wang, Sheng.(2025).Research progress on programmed cell death of cardiomyocytes in pressure-overload hypertrophic cardiomyopathy.APOPTOSIS,30,(9-10)
MLA：
Xiao, Fei,et al."Research progress on programmed cell death of cardiomyocytes in pressure-overload hypertrophic cardiomyopathy".APOPTOSIS 30..9-10(2025):2191-2224
