Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy with distinct regional variations, particularly concentrated in East Asia, including China and Japan. The Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) system offers simplicity but lacks emphasis on anatomical specificity, such as upper mediastinal metastases. Conversely, the Japan Esophageal Society (JES) system provides detailed regional stratification, aiding preoperative planning and tailored therapy, though it demands greater clinical expertise. This review evaluates the current state of pathological lymph node staging systems for ESCC, comparing the UICC/AJCC and JES approaches and exploring emerging trends in China toward station-based staging.
基金：
National Natural Science Foundation of China [82472663]; International Cooperation Projects of Science and Technology Department of Sichuan Province [2024YFHZ0322]; Sichuan Key Research and Development Project from Science and Technology Department of Sichuan Province [2023YFS0044]; Key Research and Development Project of Science and Technology Department of Chengdu [2024-YF05-00797-SN]; Doctoral Student Educational Innovation Fund Project of Kunming Medical University [2025B014]; Wu Jieping Clinical Research Projects [320.6750.2023-05-141]; Sichuan Province Clinical Key Specialty Construction Project
第一作者机构：[1]Univ Elect Sci & Technol China, Sichuan Canc Hosp, Sichuan Canc Ctr,Affiliated Canc Hosp, Dept Thorac Surg,Sichuan Clin Res Ctr Canc,Sichuan, Chengdu, Peoples R China[2]Kunming Med Univ, Affiliated Hosp 3, Yunnan Canc Hosp,Dept Thorac Surg 1, Key Lab Lung Canc Yunnan Prov,Yunnan Canc Hosp, Kunming, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Univ Elect Sci & Technol China, Sichuan Canc Hosp, Sichuan Canc Ctr,Affiliated Canc Hosp, Dept Thorac Surg,Sichuan Clin Res Ctr Canc,Sichuan, Chengdu, Peoples R China[2]Kunming Med Univ, Affiliated Hosp 3, Yunnan Canc Hosp,Dept Thorac Surg 1, Key Lab Lung Canc Yunnan Prov,Yunnan Canc Hosp, Kunming, Peoples R China
推荐引用方式(GB/T 7714)：
Li Kexun,Lu Simiao,Mao Jie,et al.Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations[J].FRONTIERS IN ONCOLOGY.2025,15:doi:10.3389/fonc.2025.1621862.
APA：
Li, Kexun,Lu, Simiao,Mao, Jie,Han, Yongtao,Peng, Lin&Leng, Xuefeng.(2025).Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations.FRONTIERS IN ONCOLOGY,15,
MLA：
Li, Kexun,et al."Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations".FRONTIERS IN ONCOLOGY 15.(2025)
