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BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis

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资源类型：
Pubmed体系：
作者：
Liu Lixin[1,2] * ; Xiong Li[3] ; Peng Hong[4] ; Deng Qin[5] ; Liu Kang[2] ; Xia Shusen[1,6] ;
机构： [1]The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of the North Sichuan Medical College, Nanchong, Sichuan, China. [2]Institute of Tissue Engineering and Stem Cell, Beijing Anzhen Nanchong Hospital of Capital Medical University, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China. [3]Department of Clinical Laboratory, People's Hospital of Leshan, Leshan, Sichuan, China. [4]Department of Anorectal Surgery, Nanchong Central Hospital, The Second clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China. [5]School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China. [6]Department of Gastrointestinal Surgery, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
出处：
DOI： 10.7717/peerj.19477

关键词： Gastric Cancer BNC1 CCL20 JAK2/STAT3

摘要：
The role of basonuclin 1 (BNC1), a zinc finger protein-specific transcription factor, in gastric cancer remains unclear. In this study, BNC1 was downregulated in gastric cancer and functioned as a tumor suppressor. Through integrative analyses of transcriptome sequencing and functional assays, C-C motif chemokine ligand 20 (CCL20) was identified as a direct downstream target of BNC1. Overexpression of BNC1 inhibited the proliferation, migration, and invasion of gastric cancer cells both in vitro and in vivo. Mechanistically, BNC1 suppresses CCL20 expression by binding to its promoter, leading to reduced activation of the JAK-STAT signaling pathway and promoting apoptosis in gastric cancer cells. These findings highlight the pivotal role of BNC1 in gastric cancer progression and suggest that targeting BNC1 and its downstream pathways could serve as a potential therapeutic strategy.©2025 Liu et al.

基金：
the Sichuan Provincial Department of Science and Natural Science Foundation of Sichuan Province of China, with the project number: 2024NSFSC0737. The research was also funded by Sichuan Provincial Administration of Traditional Chinese Medicine Subjects, with the project number: 2024MS590. Additionally, the research was supported by a project from the Leshan Municipal Health Commission,with the project number: 23SZD019.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 3 区 生物学
小类 | 3 区 综合性期刊
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 综合性期刊
第一作者：
第一作者机构： [1]The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of the North Sichuan Medical College, Nanchong, Sichuan, China. [2]Institute of Tissue Engineering and Stem Cell, Beijing Anzhen Nanchong Hospital of Capital Medical University, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China.
通讯作者：
通讯机构： [1]The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of the North Sichuan Medical College, Nanchong, Sichuan, China. [6]Department of Gastrointestinal Surgery, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
推荐引用方式(GB/T 7714)：
Liu Lixin,Xiong Li,Peng Hong,et al.BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis[J].Peerj.2025,13:e19477.doi:10.7717/peerj.19477.
APA：
Liu Lixin,Xiong Li,Peng Hong,Deng Qin,Liu Kang&Xia Shusen.(2025).BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.Peerj,13,
MLA：
Liu Lixin,et al."BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis".Peerj 13.(2025):e19477

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