Background Esophageal squamous cell carcinoma (ESCC) is prevalent in East Asia, with elderly patients facing unique postoperative challenges. This study examines the impact of seasonal variations on postoperative complications and survival in elderly patients undergoing esophagectomy for ESCC. Methods This retrospective cohort study was conducted using data from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management Database. Elderly patients (>= 70 years) with thoracic ESCC who underwent esophagectomy between May 2016 and August 2021 were included. Patients were stratified into four seasonal groups: Winter (December-February), Spring (March-May), Summer (June-August), and Autumn (September-November). Primary outcomes included overall survival (OS), disease-free survival (DFS). Secondary outcomes assessed postoperative complications using the Clavien-Dindo classification. Results A total of 469 elderly ESCC patients were included. The median overall survival was 51.6 months, with no significant differences in OS or DFS across the four seasonal groups. Restricted Mean Survival Time (RMST) and Restricted Mean Disease-Free Survival Time (RMDFST) analyses also showed no significant seasonal variations. The Summer group had a significantly higher incidence of hydrothorax compared to other groups (p < 0.05). Conclusions Seasonal variations influence specific short-term postoperative complications but do not significantly impact long-term survival in elderly ESCC patients undergoing esophagectomy.
基金:
National Natural Science Foundation of China [82472663]; National Key Research and Development Program [2022YFC2403400]; International Cooperation Projects of the Science and Technology Department of Sichuan Province [2024YFHZ0322]; Sichuan Key Research and Development Project from the Science and Technology Department of Sichuan Province [2023YFS0044]; Chengdu Science and Technology Bureau Key Research Project [2024-YF05-00797-SN]; Wu Jieping Clinical Research Projects [320.6750.2023-05-141]; Doctoral Student Educational Innovation Fund Projectof Kunming Medical University [2025B014]; Sichuan Province Clinical Key Specialty Construction Project [[2022]70]
第一作者机构:[1]Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Sch Med,Dept Thorac Surg, Chengdu 55,Sec 4 South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China[2]Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Dept Thorac Surg 1,Affiliated Hosp 3, Kunming, Peoples R China
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推荐引用方式(GB/T 7714):
Li Kexun,Lu Simiao,Li Changding,et al.Impact of seasons on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis[J].DISCOVER ONCOLOGY.2025,16(1):doi:10.1007/s12672-025-03009-w.
APA:
Li, Kexun,Lu, Simiao,Li, Changding,Mao, Jie,Zhang, Huan...&Peng, Lin.(2025).Impact of seasons on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis.DISCOVER ONCOLOGY,16,(1)
MLA:
Li, Kexun,et al."Impact of seasons on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis".DISCOVER ONCOLOGY 16..1(2025)