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Relationships Between Insomnia and Quality of Life in Patients With Advanced Liver Cancer: A Secondary Analysis of a Multicenter Cross-Sectional Study

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机构: [1]Department of Psycho‐Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China [2]Department of Gastrointestinal Cancer Unit III, Medical Insurance Service, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China [3]Department of Breast Cancer Radiotherapy, Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Medical University, Taiyuan, China [4]The Fifth Department of Chemotherapy, The Affiliated Cancer Hospital of Guangxi Medical University, Nanning, China [5]Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China [6]Department of Breast Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China [7]Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [8]Department of Oncology, Xiamen Humanity Hospital, Xiamen, China [9]Department of Integrated Chinese and Western Medicine, Shaanxi Provincial Cancer Hospital Affiliated to Medical College of Xi'an Jiaotong University, Xi'an, China [10]Department of Clinical Spiritual Care, The Affiliated Cancer Hospital of Xiangya School of Medicine, Hunan Cancer Hospital, Central South University, Changsha, China [11]Radiotherapy Center, Hubei Cancer Hospital, Wuhan, China [12]Department of Psycho‐oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China
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关键词: cancer insomnia liver cancer oncology psychological distress quality of life symptom burden

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This study aims to evaluate the symptom burden of advanced liver cancer, explore factors related to quality of life (QoL), and investigate the relationship between insomnia and QoL.This is a secondary analysis of a multicenter cross-sectional study that included data from patients with advanced liver cancer (n = 364) recruited from 10 cancer centers across China. Participants were required to complete Patient Health Questionnaire-9 (PHQ-9), MD Anderson Symptom Inventory (MDASI), Insomnia Severity Index (ISI), 5-level EQ-5D (EQ-5D-5L). Factors associated with QoL were identified through a multiple stepwise linear regression model and the LASSO regression approach. The mediating effect between insomnia and quality of life was tested using the bootstrap method.The three most prevalent symptoms were fatigue (17.0%), sleep disturbance (16.2%), and pain (15.8%). Insomnia, depression, and the 13 core symptoms in the MDASI were strongly correlated with reduced QoL (all p < 0.001). The mediating effect analysis showed that depression, dry mouth, pain, forgetfulness and fatigue were partial mediating variables between insomnia and QoL.Various physical and psychological symptoms could affect the QoL in patients with advanced liver cancer. Insomnia and related symptoms such as depression, dry mouth, pain, forgetfulness and fatigue should be identified and appropriately addressed to improve QoL for this population.© 2025 John Wiley & Sons Ltd.

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出版当年[2025]版:
大类 | 2 区 医学
小类 | 2 区 社会科学:生物医学 3 区 肿瘤学 3 区 心理学 3 区 心理学:综合
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 社会科学:生物医学 3 区 肿瘤学 3 区 心理学 3 区 心理学:综合
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第一作者机构: [1]Department of Psycho‐Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China
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