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Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor

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资源类型：
Pubmed体系：
作者：
Zhao Qixin[1] * ; Wu Jiao[3] * ; Yao Jiale[1] ; Liu Zengjin[1,4,*1] ; Li Changqiang[2] ; Sun Qin[1,4,*1] ;
机构： [1]Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000 Sichuan, China. [2]Department of Dermatology, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. [3]Chengdu University of Traditional Chinese Medicine, Chengdu 610000 Sichuan, China. [4]Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou 646000 Sichuan, China.
出处：
DOI： 10.1016/j.saa.2025.126183
ISSN：

关键词： Triple negative breast cancer Apoptosis NIR Fluorescent Inhibitor

摘要：
Triple-negative breast cancer (TNBC) is a cancerous tumor that poses a global threat to women's lives and health. Currently, chemotherapy is the preferred treatment for advanced TNBC. In this work, we have identified a novel NIR fluorescent inhibitor, SWMU690, which can effectively inhibit the proliferation of TNBC at low doses. The half-maximal inhibitory concentration (IC50) values of SWMU690 against the MDA-MB-231, 4 T1, and T47D cell lines were determined to be 104 nM, 509.4 nM, and 206 nM, respectively. We found that SWMU690 specifically localized in mitochondria to trigger mitochondria-mediated intrinsic apoptotic pathways. Furthermore, SWMU690 can suppress the production of ATP to inhibit TNBC metastasis. This study demonstrated the advantage of disrupting the function of mitochondria in inhibiting the proliferation and metastasis of TNBC, and may have other applications in the treatment of other malignant tumors.Copyright © 2025 Elsevier B.V. All rights reserved.

基金：
This research was funded by the Sichuan Science and Technology Program (No. 2024NSFSC2101) and Natural Science Project of Southwest Medical University (No. 2021ZKMS053).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 2 区 化学
小类 | 2 区 光谱学
最新[2025]版：
大类 | 2 区 化学
小类 | 2 区 光谱学
第一作者：
第一作者机构： [1]Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000 Sichuan, China.
共同第一作者：
通讯作者：
通讯机构： [1]Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000 Sichuan, China. [4]Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou 646000 Sichuan, China. [*1]182# Chunhui Road, Luzhou, Sichuan 646000, China.
推荐引用方式(GB/T 7714)：
Zhao Qixin,Wu Jiao,Yao Jiale,et al.Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor[J].Spectrochimica Acta. Part A, Molecular And Biomolecular Spectroscopy.2025,339:126183.doi:10.1016/j.saa.2025.126183.
APA：
Zhao Qixin,Wu Jiao,Yao Jiale,Liu Zengjin,Li Changqiang&Sun Qin.(2025).Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor.Spectrochimica Acta. Part A, Molecular And Biomolecular Spectroscopy,339,
MLA：
Zhao Qixin,et al."Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor".Spectrochimica Acta. Part A, Molecular And Biomolecular Spectroscopy 339.(2025):126183

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