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CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy

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资源类型：
Pubmed体系：
作者：
Li Zhuqing[1,2,3,4,5,6,7,8] * ; Si Pinxin[1,2,3,4,5,6,7] * ; Meng Tingting[1,2,3,4,5,6,7] * ; Zhao Xiaoran[1,2,3,4,5,6,7] ; Zhu Chendi[1,2,3,4,5,6,7] ; Zhang Dunfang[9] ; Meng Shutong[1,2,3,4,5,6,7] ; Li Nianyu[1,2,3,4,5,6,7] ; Liu Ran[1,2,3,4,5,6,7] ; Ni Tianxiang[1,2,3,4,5,6,7] ; Yan Junhao[1,2,3,4,5,6,7] ; Li Hongchang[1,2,3,4,5,6,7] ; Zhao Ning[10] ; Zhong Chao[11] ; Qin Yingying[1,2,3,4,5,6,7,8] ; Chen WanJun[12] ; Chen Zi-Jiang[1,2,3,4,5,6,7,13,14] ; Jiao Xue[1,2,3,4,5,6,7] ;
机构： [1]State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Second Hospital, Shandong University, Jinan, Shandong 250012, China. [2]National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong 250012, China. [3]Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong 250012, China. [4]Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong 250012, China. [5]Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong 250012, China. [6]Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong 250012, China. [7]Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong 250012, China. [8]Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China. [9]Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. [10]Analytical Biosciences Limited, Beijing 100191, China. [11]Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-Related Diseases, Peking University, Beijing 100191, China. [12]Mucosal Immunology Section, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. [13]Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China. [14]Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出处：
DOI： 10.1126/sciimmunol.ado2463

摘要：
Regulatory T (Treg) cells play a vital role in maintaining maternal immune tolerance to the semiallogeneic fetus during pregnancy. Treg cell population heterogeneity and tissue-specific functions in the human decidua remain largely unknown. Here, using single-cell transcriptomic and T cell receptor sequencing of human CD4+ T cells from first-trimester deciduae and matched peripheral blood of pregnant women, we identified a highly activated, immunosuppressive CCR8+ Treg cell subset specifically enriched in the decidua (dTreg cells). CCR8+ dTreg cells were decreased in patients with recurrent pregnancy loss (RPL) and an abortion-prone mouse model. Depletion of CCR8+ dTreg cells increased susceptibility to fetal loss, with altered decidual immune profiles. Adoptive transfer of CCR8+ Treg cells rescued fetal loss in abortion-prone mice. The CCR8 ligand CCL1 was mainly produced by decidual CD49a+ natural killer cells and was significantly decreased in patients with RPL. Our data demonstrate that CCR8+ dTreg cells are required to maintain maternal-fetal tolerance and highlight potential avenues for RPL therapies.

基金：
National Key Research and Development Program of China (2022YFA1103600 to X.J. and C.Z. and 2022YFC2703800 to Y.Q.), the National Natural Science Foundation of China (82371679 and 82171651 to X.J. and 82421004 and 82125014 to Y.Q.), the Distinguished Young Scholars and Taishan Scholars Program for Young Experts of Shandong Province (ZR2022YQ68 and tsqn202211372 to X.J.), the Shandong Provincial Natural Science Foundation (ZR2023QH337 to Z.L.), and the Research Project on Laboratory Construction and Management at Shandong University (sy20243407 to X.J.).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 免疫学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 免疫学
第一作者：
第一作者机构： [1]State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Second Hospital, Shandong University, Jinan, Shandong 250012, China. [2]National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong 250012, China. [3]Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong 250012, China. [4]Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong 250012, China. [5]Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong 250012, China. [6]Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong 250012, China. [7]Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong 250012, China. [8]Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Second Hospital, Shandong University, Jinan, Shandong 250012, China. [2]National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong 250012, China. [3]Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong 250012, China. [4]Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong 250012, China. [5]Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong 250012, China. [6]Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong 250012, China. [7]Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong 250012, China. [13]Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China. [14]Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
推荐引用方式(GB/T 7714)：
Li Zhuqing,Si Pinxin,Meng Tingting,et al.CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy[J].Science Immunology.2025,10(106):eado2463.doi:10.1126/sciimmunol.ado2463.
APA：
Li Zhuqing,Si Pinxin,Meng Tingting,Zhao Xiaoran,Zhu Chendi...&Jiao Xue.(2025).CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy.Science Immunology,10,(106)
MLA：
Li Zhuqing,et al."CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy".Science Immunology 10..106(2025):eado2463

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