个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：

收录情况： ◇ 自然指数

作者：
Li Wenxue[1,2] * ; Dasgupta Abhijit[3,8] * ; Yang Ka[3,9] * ; Wang Shisheng[4] * ; Hemandhar-Kumar Nisha[5] ; Chepyala Surendhar R[3] ; Yarbro Jay M[3] ; Hu Zhenyi[2,10] ; Salovska Barbora[1,2] ; Fornasiero Eugenio F[5,6] ; Peng Junmin[3] ; Liu Yansheng[1,2,7] ;
机构： [1]Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA [2]Cancer Biology Institute, Yale University School of Medicine, West Haven, CT 06516, USA [3]Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA [4]Department of General Surgery and Liver Transplant Center, Proteomics-Metabolomics Analysis Platform, West China Hospital, Sichuan University, Chengdu 610041, China [5]Department of Neuro- and Sensory Physiology, University Medical Center Go¨ ttingen, 37073 Go¨ ttingen, Germany [6]Department of Life Sciences, University of Trieste, 34127 Trieste, Italy [7]Department of Biomedical Informatics & Data Science, Yale University School of Medicine, New Haven, CT 06510, USA [8]Department of Computer Science and Engineering, SRM University AP, Neerukonda, Guntur, Andhra Pradesh 522240, India [9]Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA [10]Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
出处：
DOI： 10.1016/j.cell.2025.02.021
ISSN：

摘要：
Understanding how proteins in different mammalian tissues are regulated is central to biology. Protein abundance, turnover, and post-translational modifications such as phosphorylation are key factors that determine tissue-specific proteome properties. However, these properties are challenging to study across tissues and remain poorly understood. Here, we present Turnover-PPT, a comprehensive resource mapping the abundance and lifetime of 11,000 proteins and 40,000 phosphosites in eight mouse tissues and various brain regions using advanced proteomics and stable isotope labeling. We reveal tissue-specific short- and long-lived proteins, strong correlations between interacting protein lifetimes, and distinct impacts of phosphorylation on protein turnover. Notably, we discover a remarkable pattern of turnover changes for peroxisome proteins in specific tissues and that phosphorylation regulates the stability of neurodegeneration-related proteins, such as Tau and α-synuclein. Thus, Turnover-PPT provides fundamental insights into protein stability, tissue dynamic proteotypes, and functional protein phosphorylation and is accessible via an interactive web-based portal at https://yslproteomics.shinyapps.io/tissuePPT.Copyright © 2025 Elsevier Inc. All rights reserved.

基金：
Y.L. thanks the support from the National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH) through grants R01GM137031 and RM1GM149406. J.P. is supported by RF1AG064909, RF1AG068581, and U19AG069701 from NIH. E.F.F. is supported by a CZI Collaborative Pairs Pilot Project Awards (cycle 2; phase 1). E.F.F. also acknowledges the support of the SFB1286, Go¨ ttingen, Germany. We would like to thank Drs. Yun Jiao and Zhiping Wu for preparing the pSILAC mice and Drs. Mandar Muzumdar and Ines Chen for their critical comments on the manuscript
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
第一作者：
第一作者机构： [1]Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA [2]Cancer Biology Institute, Yale University School of Medicine, West Haven, CT 06516, USA
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA [2]Cancer Biology Institute, Yale University School of Medicine, West Haven, CT 06516, USA [5]Department of Neuro- and Sensory Physiology, University Medical Center Go¨ ttingen, 37073 Go¨ ttingen, Germany [6]Department of Life Sciences, University of Trieste, 34127 Trieste, Italy [7]Department of Biomedical Informatics & Data Science, Yale University School of Medicine, New Haven, CT 06510, USA
推荐引用方式(GB/T 7714)：
Li Wenxue,Dasgupta Abhijit,Yang Ka,et al.Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions[J].Cell.2025,doi:10.1016/j.cell.2025.02.021.
APA：
Li Wenxue,Dasgupta Abhijit,Yang Ka,Wang Shisheng,Hemandhar-Kumar Nisha...&Liu Yansheng.(2025).Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions.Cell,,
MLA：
Li Wenxue,et al."Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions".Cell .(2025)

资源点击量：57692 今日访问量：0 总访问量：4768 更新日期：2025-05-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号