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The establishment and regulation of human germ cell lineage

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机构： [1]Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, UniversityUniversity of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining 314400, Zhejiang, China [2]College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, Sichuan, China [3]Center for Global Health Research, Usher Institute, University of Edinburgh, 5-7 Little France Road, Edinburgh EH16 4UX, UK [4]Zhejiang University - University of Edinburgh Institute, Zhejiang University, Haining 314400, Zhejiang, China [5]Center for Reproductive Medicine of The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China [6]Center for Infection Immunity, Cancer of Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China [7]State Key Laboratory of Biobased Transportation Fuel Technology, Haining 314400, Zhejiang, China [8]Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, Zhejiang, China

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The specification of primordial germ cells (PGCs) during early embryogenesis initiates the development of the germ cell lineage that ensures the perpetuation of genetic and epigenetic information from parents to offspring. Defects in germ cell development may lead to infertility or birth defects. Historically, our understanding of human PGCs (hPGCs) regulation has primarily been derived from studies in mice, given the ethical restrictions and practical limitations of human embryos at the stage of PGC specification. However, recent studies have increasingly highlighted significant mechanistic differences for PGC development in humans and mice. The past decade has witnessed the establishment of human pluripotent stem cell (hPSC)-derived hPGC-like cells (hPGCLCs) as new models for studying hPGC fate specification and differentiation. In this review, we systematically summarize the current hPSC-derived models for hPGCLC induction, and how these studies uncover the regulatory machinery for human germ cell fate specification and differentiation, forming the basis for reconstituting gametogenesis in vitro from hPSCs for clinical applications and disease modeling.© 2025. The Author(s).

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出版当年[2025]版：

大类 | 2 区

医学

小类 | 2 区细胞与组织工程 2 区细胞生物学 2 区医学：研究与实验

最新[2025]版：

大类 | 2 区

医学

小类 | 2 区细胞与组织工程 2 区细胞生物学 2 区医学：研究与实验

第一作者：

第一作者机构： [1]Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, UniversityUniversity of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining 314400, Zhejiang, China

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通讯作者：

通讯机构： [1]Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, UniversityUniversity of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining 314400, Zhejiang, China [7]State Key Laboratory of Biobased Transportation Fuel Technology, Haining 314400, Zhejiang, China [8]Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, Zhejiang, China

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