机构:[1]Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.四川大学华西医院[2]Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, Zhejiang, China.[3]Centre for Translational Research in Cancer, Sichuan Cancer Hospital & Institute, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610042, China.四川省肿瘤医院
In recent years, the introduction of mRNA vaccines for SARS-CoV2 and RSV has highlighted the success of the mRNA technology platform. Designing mRNA sequences involves multiple components and requires balancing several parameters, including enhancing transcriptional efficiency, boosting antigenicity, and minimizing immunogenicity. Moreover, changes in the composition and properties of delivery vehicles can also affect vaccine performance. Traditional methods of experimentally testing these conditions are time-consuming, labor-intensive and costly, necessitating advanced optimization strategies. Recently, the rapid development of computational tools has significantly accelerated the optimization process for mRNA vaccines. In this review, we systematically examine computation-aided approaches for optimizing mRNA components, including coding and non-coding regions, and for improving the efficiency of lipid nanoparticle (LNP) delivery systems by focusing on their composition, ratios, and characterization. The use of computational tools can significantly accelerate mRNA vaccine development, enabling rapid responses to emerging infectious diseases and supporting the development of precise, personalized therapies. These approaches may guide the future direction of mRNA vaccine development. Our review aims to provide integrated constructive support for computer-aided mRNA vaccine design.
基金:
National Key Research and Development
Program of China (2023YFC3403200), the Fund of Wenzhou Institute University of Chinese
Academy of Sciences, Key Research and Development Grant of MOST (2023YFA095000),
and NSFC (82470005).
语种:
外文
PubmedID:
中科院(CAS)分区:
出版当年[2025]版:
大类|2 区医学
小类|2 区生理学
最新[2025]版:
大类|2 区医学
小类|2 区生理学
第一作者:
第一作者机构:[1]Department of Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Zhao Siyu,Chen Jingjing,Dai Tian,et al.Harnessing Computational Strategies to Overcome Challenges in mRNA Vaccines[J].Physiology (Bethesda, Md.).2025,doi:10.1152/physiol.00047.2024.
APA:
Zhao Siyu,Chen Jingjing,Dai Tian,Li Guohong,Huang Letao...&Song Xiangrong.(2025).Harnessing Computational Strategies to Overcome Challenges in mRNA Vaccines.Physiology (Bethesda, Md.),,
MLA:
Zhao Siyu,et al."Harnessing Computational Strategies to Overcome Challenges in mRNA Vaccines".Physiology (Bethesda, Md.) .(2025)