Gastrointestinal cancers including esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), and colorectal cancer (CRC) are common and highly lethal types of cancer worldwide. Metabolic reprogramming plays a critical role in cancer progression and involves metabolic processes such as glucose and lipid metabolism. Fatty acid oxidation (FAO) has a profound impact on cancer, with many genes and cytokines influencing cancer cell initiation, development, metastasis, and resistance by regulating FAO. Additionally, FAO further promotes cancer progression by affecting the tumor microenvironment (TME). The role of FAO in gastrointestinal cancers has garnered increasing attention, and related anticancer drugs are currently being developed.
基金：
National Key Research and Development Program of China
第一作者机构：[1]Wenzhou Med Univ, Zhejiang Canc Hosp, Postgrad Training Base Alliance, Hangzhou, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zheng Yingsong,Jiang Zhengchen,Yuan Li,et al.Targeting fatty acid oxidation: A potential strategy for treating gastrointestinal tumors[J].INTERNATIONAL JOURNAL OF CANCER.2025,doi:10.1002/ijc.35380.
APA：
Zheng, Yingsong,Jiang, Zhengchen,Yuan, Li,Cheng, Xiangdong,He, Weiyang&Chen, Xiaodong.(2025).Targeting fatty acid oxidation: A potential strategy for treating gastrointestinal tumors.INTERNATIONAL JOURNAL OF CANCER,,
MLA：
Zheng, Yingsong,et al."Targeting fatty acid oxidation: A potential strategy for treating gastrointestinal tumors".INTERNATIONAL JOURNAL OF CANCER .(2025)
