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Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

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收录情况： ◇ 自然指数

作者：
Xu Qiang[1] * ; Lui Su[2] * ; Ji Yuan[1] * ; Cheng Jingliang[3] ; Zhang Long Jiang[4] ; Zhang Bing[5] ; Zhu Wenzhen[6] ; Geng Zuojun[7] ; Cui Guangbin[8] ; Zhang Quan[9] ; Liao Weihua[10,11,12] ; Yu Yongqiang[13] ; Zhang Hui[14] ; Gao Bo[15,16] ; Xu Xiaojun[17] ; Han Tong[18] ; Yao Zhenwei[19] ; Qin Wen[1] ; Liu Feng[1] ; Liang Meng[20] ; Fu Jilian[1] ; Xu Jiayuan[1] ; Zhang Peng[21] ; Li Wei[21] ; Shi Dapeng[22] ; Wang Caihong[3] ; Gao Jia-Hong[23] ; Yan Zhihan[24] ; Chen Feng[25] ; Li Jiance[26] ; Zhang Jing[27,28] ; Wang Dawei[29] ; Shen Wen[30] ; Miao Yanwei[31] ; Xian Junfang[32] ; Wang Meiyun[22] ; Ye Zhaoxiang[21] ; Zhang Xiaochu[33] ; Zuo Xi-Nian[34,35] ; Xu Kai[36] ; Qiu Shijun[37,38] ; Yu Chunshui[39,40] ;
机构： [1]Department of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China. [2]Department of Radiology, the Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China. [3]Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [4]Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. [5]Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. [6]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [7]Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China. [8]Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, China. [9]Department of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China. [10]Department of Radiology, Xiangya Hospital, Central South University, Changsha, China. [11]Molecular Imaging Research Center of Central South University, Changsha, China. [12]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. [13]Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. [14]Department of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, China. [15]Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. [16]Department of Radiology, Yantai Yuhuangding Hospital, Yantai, China. [17]Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China. [18]Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China. [19]Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China. [20]School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China. [21]Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. [22]Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China. [23]Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. [24]Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. [25]Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China. [26]Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [27]Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China. [28]Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China. [29]Department of Radiology, Qilu Hospital of Shandong University, Jinan, China. [30]Department of Radiology, Tianjin First Center Hospital, Tianjin, China. [31]Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China. [32]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [33]Division of Life Science and Medicine, University of Science & Technology of China, Hefei, China. [34]IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China. [35]Institute of Psychology, Chinese Academy of Sciences, Beijing, China. [36]Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. [37]Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [38]Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. [39]Department of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China. [40]CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
出处：
DOI： 10.1038/s41593-025-01882-w
ISSN：

摘要：
Socioeconomic status (SES) is a time-varying multidimensional construct with ill-defined dimension-specific and age-specific effects on brain and behavior. We investigated these effects in 4,228 young adults. From 16 socioeconomic indicators, assessed for early (0-10 years) and late (>10 years) stages, we constructed family, provincial, family adverse and neighborhood adverse socioeconomic dimensions. Generally, family SES was associated with brain structure and connectivity along with cognitive function, whereas family adverse and neighborhood adverse SES were associated with personality and emotion. Most associations were observed for both early and late-stage SES; however, adjusting for the effect of early stage SES revealed late-stage-specific SES effects. Changes in SES were associated with personality and cognitive function. Cerebellar and medial frontal volumes and functional connectivity within the left frontoparietal network mediated the associations between family SES and memory and openness. These results inform both more precise interventions for reducing the consequences of adverse SES and experimental designs for excluding confounding socioeconomic effects on human health.© 2025. The Author(s), under exclusive licence to Springer Nature America, Inc.

基金：
This work was funded by the Natural Science Foundation of China (grant nos. 82430063 and 82030053 to C.Y., 82330058 and T2341014 to S.Q., 82001796 to Q.X., 82371924 to J.Xu), Tianjin Applied Basic Research Multi-fund Project (grant no. 21JCQNJC01010 to Q.X.), New Star of Excellence Project of Tianjin Medical University General Hospital (grant no. 209060403205 to Q.X.), Tianjin Key Medical Discipline (Specialty) Construction Project (grant no. TJYXZDXK-001A to C.Y.) and National Key Project of 'Inter-governmental International Scientific and Technological Innovation Cooperation' to J. Xu (grant no. 2023YFE0199700), the Tianjin Young Talents in Science and Technology for J. Xu (grant no. QN20230336), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences to J. Xu (grant no. 2024-JKCS-18), the Tianjin Science and Technology Commission Major Special Project in Public Health Science and Technology to J. Xu (grant no. 24ZXGQSY00050) and the Tianjin Medical University 'Clinical Talent Training 123 Climbing Plan' to J. Xu.
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外文
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出版当年[2025]版：
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最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 神经科学
第一作者：
第一作者机构： [1]Department of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China.
共同第一作者：
通讯作者：
通讯机构： [37]Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [38]Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. [39]Department of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China. [40]CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
推荐引用方式(GB/T 7714)：
Xu Qiang,Lui Su,Ji Yuan,et al.Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits[J].Nature Neuroscience.2025,doi:10.1038/s41593-025-01882-w.
APA：
Xu Qiang,Lui Su,Ji Yuan,Cheng Jingliang,Zhang Long Jiang...&Yu Chunshui.(2025).Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits.Nature Neuroscience,,
MLA：
Xu Qiang,et al."Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits".Nature Neuroscience .(2025)

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