机构：[1]Department of Radiology, Huaxi MR Research Center (HMRRC), Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610000, Sichuan Province, China.四川大学华西医院[2]Institute for Bioengineering of Catalunya (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona (Spain), Carrer Baldiri I Reixac, 08028, Barcelona, Spain.[3]Department of Electronic and Biomedical Engineering, University of Barcelona, Marti i Franques 1, 08028, Barcelona, Spain.[4]Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.[5]Department of Applied Physics, University of Barcelona, Marti i Franques 1, 08028, Barcelona, Spain.[6]Functional and Molecular Imaging Key Laboratory of Sichuan Province, and Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China.[7]Catalan Institution for Research and Advanced Studies (ICREA), Passeig de Lluis Companys, 23, 08010, Barcelona, Spain.
Nanoparticle (NP) morphology holds significant importance in nanomedicine, particularly concerning its implications for biological responses. This study investigates the impact of synthesizing polymers with varying degrees of methionine (MET) polymerization on three distinct drug delivery systems: spherical micelles, worm-like micelles, and vesicles, all loaded with the photosensitizer chlorin e6 (Ce6). We analyzed their distribution at both cellular and animal levels, revealing how NP morphology influences cellular uptake, subcellular localization, penetration of multicellular spheroids, blood half-life, and biodistributions across major organs. Employing a physiologically based pharmacokinetic (PBPK) model enabled us to simulate diverse distribution patterns and quantify the targeting efficiency of NPs toward tumors. Our investigation elucidates that spherical micelles exhibit lower accumulation levels within the reticuloendothelial system, potentially mitigating adverse side effects despite their higher glomerular filtration rate. This nuanced understanding underscores the complex interplay between NP morphology and biological responses, providing valuable insights into optimizing therapeutic efficacy while minimizing undesirable effects. We thus report the integration of experimental analyses with PBPK modeling to elucidate the topological characteristics of NP, thereby shedding light on their distribution patterns, therapeutic efficacy, and potential side effects.
基金：
This research was financially supported by the National Natural
Science Foundation of China (32171001, 52103175), the
National Clinical Research Center for Geriatrics, West China
Hospital, Sichuan University (Z2021YY001), and Post-Doctor
Research Project, West China Hospital, Sichuan University
(2021HXBH055).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类|3 区医学
小类|3 区材料科学：生物材料
第一作者：
第一作者机构：[1]Department of Radiology, Huaxi MR Research Center (HMRRC), Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610000, Sichuan Province, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology, Huaxi MR Research Center (HMRRC), Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610000, Sichuan Province, China.[2]Institute for Bioengineering of Catalunya (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona (Spain), Carrer Baldiri I Reixac, 08028, Barcelona, Spain.[3]Department of Electronic and Biomedical Engineering, University of Barcelona, Marti i Franques 1, 08028, Barcelona, Spain.[4]Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.[6]Functional and Molecular Imaging Key Laboratory of Sichuan Province, and Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, 610041, China.[7]Catalan Institution for Research and Advanced Studies (ICREA), Passeig de Lluis Companys, 23, 08010, Barcelona, Spain.
推荐引用方式(GB/T 7714)：
Ding Haitao,Su Liping,Xie Zhendong,et al.Morphological insights in oxidative sensitive nanocarrier pharmacokinetics, targeting, and photodynamic therapy[J].Journal Of Materials Chemistry. B.2025,doi:10.1039/d4tb02194k.
APA：
Ding Haitao,Su Liping,Xie Zhendong,Castano Aroa Duro,Li Yunkun...&Battaglia Giuseppe.(2025).Morphological insights in oxidative sensitive nanocarrier pharmacokinetics, targeting, and photodynamic therapy.Journal Of Materials Chemistry. B,,
MLA：
Ding Haitao,et al."Morphological insights in oxidative sensitive nanocarrier pharmacokinetics, targeting, and photodynamic therapy".Journal Of Materials Chemistry. B .(2025)
