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Therapeutic strategies and landscape of metaplastic breast cancer

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机构： [1]Breast Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China [2]West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, PR China [3]Institute of Breast Health Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China

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关键词： Metaplastic breast cancer Treatment Novel strategies Targeted therapy Immunotherapy

摘要：

Metaplastic breast cancer is a rare and heterogeneous subtype of breast cancer, associated with a poor prognosis. Its distinct biological behavior and morphological features contribute to resistance to standard treatment regimens. Hitherto, the optimal therapeutic strategy for metaplastic breast cancer remains underexplored. Herein, we review the literature on the treatment of metaplastic breast cancer, summarizing current local and systemic therapies, and discuss potential therapeutic targets and novel strategies based on its pathological and molecular characteristics. Targeted therapy and immunotherapy may provide more personalized treatment options, with the potential to improve the prognosis of this disease.Copyright © 2025 Elsevier Ltd. All rights reserved.

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最新[2023]版

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大类 | 1 区

医学

小类 | 2 区肿瘤学

第一作者：

第一作者机构： [1]Breast Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China [2]West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, PR China

通讯作者：

通讯机构： [1]Breast Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China [3]Institute of Breast Health Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China

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