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Efficacy and Safety of Switching from Baricitinib to Ritlecitinib in Severe Alopecia Areata

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机构: [1]Department of Dermatology, the First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, Fujian, China. [2]Department of Dermatology, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, Sichuan, China. [3]Fujian Dermatology and Venereology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. [4]Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. [5]Central Laboratory, the First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, Fujian, China.
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Dear Editor, Janus kinase (JAK) inhibitors are considered the optimal systemic therapy for adults with severe alopecia areata (AA).1,2 Baricitinib, a JAK1/2 inhibitor, was the first systemic JAK inhibitor (JAKi) used for AA on-label. 1,2 However, some patients demonstrated an inadequate or no response to baricitinib.1,2 Subsequently, ritlecitinib, a JAK3/tyrosine kinase (TEC) inhibitor was approved for treating severe AA. 3 Currently, there are no reports addressing the efficacy of ritlecitinib in patient with inadequate or no response to baricitinib. To fill this gap, we conducted a retrospective case series to explore the efficacy and safety of switching from baricitinib to ritlecitinib in severe AA.

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大类 | 4 区 医学
小类 | 4 区 皮肤病学
第一作者:
第一作者机构: [1]Department of Dermatology, the First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, Fujian, China. [2]Department of Dermatology, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, Sichuan, China.
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通讯作者:
通讯机构: [1]Department of Dermatology, the First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, Fujian, China. [3]Fujian Dermatology and Venereology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. [4]Key Laboratory of Skin Cancer of Fujian Higher Education Institutions, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
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