机构：[1]Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, China.[2]Nanchong Institute of Cerebrovascular Diseases, Nanchong, China.[3]Sichuan Clinical Research Center for Neurological Disease, Nanchong, China.[4]Department of Pathology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.[5]Department of Neurosurgery, Chongqing General Hospital, Chongqing University, Chongqing, China.
Existing evidence suggests that miscarriage and stillbirth are associated with an increased risk of stroke in women. However, the impact of these events on stroke mortality remains unclear. This study aimed to elucidate the potential association between miscarriage and stillbirth and stroke mortality in women.We employed a competing risk model using data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial to assess the relationship between miscarriage/stillbirth and stroke death. Death from other causes was considered as a competing risk, and we conducted a subgroup analysis to explore the potential impact.Our study included 68,629 women for miscarriage and 65,343 women for stillbirth. No significant association was observed between miscarriage and stroke mortality (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.84 to 1.10; p=0.58). While a single stillbirth did not show a significant association (HR, 0.81; 95% CI, 0.57 to 1.15; p=0.23), recurrent stillbirth (≥2) was associated with a significantly increased risk of stroke mortality compared to women with no stillbirths (HR, 2.24; 95% CI, 1.45 to 3.46; p<0.001).Our findings suggest that recurrent stillbirth, but not single events, is associated with an elevated risk of stroke mortality in women. Further research is warranted to clarify the underlying mechanisms and potential long-term health implications of recurrent pregnancy loss.
基金：
Research and
Development Foundation of Bureau of Science & Technology
and Intellectual Property Nanchong City (20SXQT0081) and Research Startup Fund from Nanchong Central Hospital.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类|4 区医学
小类|4 区公共卫生、环境卫生与职业卫生
第一作者：
第一作者机构：[1]Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, China.[2]Nanchong Institute of Cerebrovascular Diseases, Nanchong, China.[3]Sichuan Clinical Research Center for Neurological Disease, Nanchong, China.
通讯作者：
通讯机构：[1]Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, China.[2]Nanchong Institute of Cerebrovascular Diseases, Nanchong, China.[3]Sichuan Clinical Research Center for Neurological Disease, Nanchong, China.[5]Department of Neurosurgery, Chongqing General Hospital, Chongqing University, Chongqing, China.
推荐引用方式(GB/T 7714)：
Tang Hui,Li Zhou,Zhang Yuan,et al.Miscarriage, stillbirth, and mortality risk from stroke in women: findings from the PLCO study[J].Epidemiology And Health.2024,46:e2024093.doi:10.4178/epih.e2024093.
APA：
Tang Hui,Li Zhou,Zhang Yuan,Dai Mingjun,Wang Xiaoya&Shao Chuan.(2024).Miscarriage, stillbirth, and mortality risk from stroke in women: findings from the PLCO study.Epidemiology And Health,46,
MLA：
Tang Hui,et al."Miscarriage, stillbirth, and mortality risk from stroke in women: findings from the PLCO study".Epidemiology And Health 46.(2024):e2024093
