详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Single-cell atlas comparison across vertebrates reveals auditory cell evolution and mechanisms for hair cell regeneration

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China. [2]University of Chinese Academy of Sciences, Beijing, China. [3]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, 100142, China. [4]Institute of Blood Diseases, Department of Hematology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Chengdu, 610072, China. [5]Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. [6]College of Agronomy, Sichuan Agricultural University, Chengdu, China. [7]Center for Precision Medicine Multi-Omics Research, Institute of Advanced Clinical Medicine, Peking University, Beijing, 100191, China.

出处：

DOI：

摘要：

Mammals suffer permanent hearing impairment from the loss of auditory hair cells due to their inability to regenerate. In contrast, lower vertebrates exhibit extraordinary capacity for hair cell regeneration and hearing restoration, but the mechanisms remain unclear. Here we characterize the single-cell atlas of Xenopus laevis inner ear and perform a comprehensive comparison with mouse model. An exceptionally conserved inner ear neuronal cell type is discovered. The results reveal that the outer hair cells (OHCs) exist exclusively in mammals. Importantly, our analyses reveal an orchestrated gene expression program in Xenopus, characterized by upregulation of hair cell regeneration-related genes, coupled with downregulation of proliferation inhibitory genes. These findings unveil a natural feature of regenerative capacity in Xenopus, and provide molecular and evolutionary evidences for differential regenerative capacities across vertebrates. This work offers insights from amphibians into developing strategies to solve the challenges of hair cell regeneration in humans.© 2024. The Author(s).

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2024]版：

无

最新[2023]版：

大类 | 1 区

生物学

小类 | 1 区生物学

第一作者：

第一作者机构： [1]Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China. [2]University of Chinese Academy of Sciences, Beijing, China.

共同第一作者：

通讯作者：

通讯机构： [3]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, 100142, China. [5]Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. [7]Center for Precision Medicine Multi-Omics Research, Institute of Advanced Clinical Medicine, Peking University, Beijing, 100191, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：