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Noble Metal Nanoparticle Assisted Mass Spectrometry for Metabolite-Based In Vitro Diagnostics

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资源类型：
Pubmed体系：
作者：
Liu Yanling[1] * ; Yang Shouzhi[1] ; Li Shunxiang[1] ; Wang Yuning[1] ; Liu Xiaohui[1] ; Xu Wei[2] ; Su Haiyang[1] ; Qian Kun[1] ;
机构： [1]State Key Laboratory of Systems Medicine for Cancer, School of Biomedical Engineering, Institute of Medical Robotics and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China. [2]Division of Cardiology, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.
出处：
DOI： 10.1002/smll.202409714
ISSN：

摘要：
In vitro diagnostics (IVD) makes clinical diagnosis rapid, simple, and noninvasive to patients, playing a crucial role in the early diagnosis and monitoring of diseases. Metabolic biomarkers are closely correlated to the phenotype of diseases. However, most IVD platforms are constrained by the sensitivity and throughput of assay. In recent years, noble-metal-nanoparticle (NMNP)-assisted laser desorption/ionization mass spectrometry (LDI MS) has generated major advances in metabolite analysis, significantly improving the sensitivity, accuracy, and throughput of IVD due to the unique optical and electrical properties of NMNPs. This review systematically assesses the development of NMNPs as LDI MS matrices in the detection of metabolites for IVD application. The analysis of several NMNP structures, such as core-shell, porous, and 2D nanoparticles, elucidates their significant contribution to the enhancement of MS performance. Furthermore, the recent advancements in the application of NMNPs for diagnosing various systemic diseases are summarized. Finally, the prospects and challenges of NMNP-assisted MS for IVD are discussed. This review elucidates the roles of NMNPs' structure in enhancing MS-based metabolic detection and provides an overview of various IVD applications, consequently offering comprehensive insights for researchers and developers in this field.© 2024 Wiley‐VCH GmbH.

基金：
The authors are grateful for the financial support from Projects (Nos. 82402498, 81971771, 22204103) by the NSFC, Projects (Nos. 2022YFE0103500, 2021YFF0703500) by the National Key R&D Program of China, the Medical-Engineering Joint Funds of Shanghai Jiao Tong University (Grant Nos. YG2021ZD09, YG2023ZD08, YG2024ZD07, YG2023QNA12), Project No. 2022XYJG0001-01-16 by the Shanghai Jiao Tong University Inner Mongolia Research Institute, Project No. BX2021182 by the China Postdoctoral Science Foundation, Project No. 2021-01-07-00-02-E00083 by the Shanghai Institutions of Higher Learning, Project No. 2024YFHZ0176 by the Sichuan Provincial Department of Science and Technology, and the Innovative Research Team of High-Level Local Universities in Shanghai (Grant No. SHSMU-ZDCX20210700). This work was also sponsored by the Innovation Group Project of Shanghai Municipal Health Commission (Grant No. 2019CXJQ03), the Innovation Research Plan by the Shanghai Municipal Education Commission (Grant No. ZXWF082101), the Science and Technology Commission of Shanghai Municipality (Grant Nos. 20DZ2220400, 2021SHZDZX), the National Research Center for Translational Medicine Shanghai (Grant Nos. TMSK2021-124, NRCTM(SH)-2021-06).
语种：
外文
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中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 2 区 材料科学
小类 | 1 区 物理：应用 2 区 化学：综合 2 区 物理化学 2 区 材料科学：综合 2 区 纳米科技 2 区 物理：凝聚态物理
第一作者：
第一作者机构： [1]State Key Laboratory of Systems Medicine for Cancer, School of Biomedical Engineering, Institute of Medical Robotics and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China.
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Yanling,Yang Shouzhi,Li Shunxiang,et al.Noble Metal Nanoparticle Assisted Mass Spectrometry for Metabolite-Based In Vitro Diagnostics[J].Small (Weinheim An Der Bergstrasse, Germany).2024,e2409714.doi:10.1002/smll.202409714.
APA：
Liu Yanling,Yang Shouzhi,Li Shunxiang,Wang Yuning,Liu Xiaohui...&Qian Kun.(2024).Noble Metal Nanoparticle Assisted Mass Spectrometry for Metabolite-Based In Vitro Diagnostics.Small (Weinheim An Der Bergstrasse, Germany),,
MLA：
Liu Yanling,et al."Noble Metal Nanoparticle Assisted Mass Spectrometry for Metabolite-Based In Vitro Diagnostics".Small (Weinheim An Der Bergstrasse, Germany) .(2024):e2409714

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