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Multifunctional hybrid poly(ester-urethane)urea/resveratrol electrospun nanofibers for a potential vascularizing matrix

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机构: [1]Multidisciplinary Centre for Advanced Materials, Institute for Frontier Medical Technology, School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Rd., Shanghai 201620, P. R. China. [2]Department of Minimally Invasive Spine Surgery, Shandong Wendeng Orthopedic Hospital, 1 Fengshan Rd., Weihai 264400, Shandong, P. R. China. [3]Orthopedics Research Institute, Trauma Medical Center, Department of Orthopedics, West China Hospital, Sichuan University, 37 Guoxue Ln., Chengdu 610041, Sichuan, P. R. China. [4]Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Rd., Shanghai 200025, P. R. China. [5]Shanghai Key Laboratory of Pancreatic Neoplasms Translational Medicine, 197 Ruijin 2nd Rd., Shanghai 200025, P. R. China. [6]Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Rd., Shanghai 200025, P. R. China. [7]Department of Plastic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, 16766 Jingshi Rd., Jinan 250014, Shandong, P. R. China. [8]Jinan Clinical Research Center for Tissue Engineering Skin Regeneration and Wound Repair, 16766 Jingshi Rd., Jinan 250014, Shangdong, P. R. China.
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The challenges for clinical application of small-diameter vascular graft are mainly acute/chronic thrombosis, inadequate endothelialization, intimal hyperplasia caused by inflammation, oxidative stress, and the mismatch of mechanical compliance after transplantation. How to construct an effective regenerative microenvironment through a material with uniform dispersion of active components is the premise of maintaining patency of a vascular graft. In this study, we have compounded poly(ester-urethane)urea (PEUU) with various optimized concentrations of resveratrol (Res) by homogeneous emulsion blending, followed by electrospinning into the hybrid PEUU/Res nanofibers (P/R-0, P/R-0.5, P/R-1.0, and P/R-1.5). Then the microstructure, surface wettability, mechanical properties, degradation, Res sustained release properties, hemocompatibility, and cytocompatibility of P/R were evaluated comprehensively. The results indicate that Res can be gradually released from the P/R, and both the hydrophilicity and antioxidant ability of the nanofiber gradually increase with the increase of Res content. Moreover, with the increase of Res, the viability and proliferation behavior of HUVECs were significantly improved. Meanwhile, tube formation and migration experiments showed that Res promoted the formation of a neovascularization network. In brief, it is concluded that P/R-1.0 is the optimal candidate with a uniform microstructure, moderate wettability, optimized mechanical properties, reliable hemocompatibility and cytocompatibility, and strongest ability to promote endothelial growth for the vascularizing matrix.

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大类 | 3 区 化学
小类 | 2 区 高分子科学 3 区 物理化学 3 区 材料科学:综合 3 区 物理:综合
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第一作者机构: [1]Multidisciplinary Centre for Advanced Materials, Institute for Frontier Medical Technology, School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Rd., Shanghai 201620, P. R. China.
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通讯机构: [4]Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Rd., Shanghai 200025, P. R. China. [5]Shanghai Key Laboratory of Pancreatic Neoplasms Translational Medicine, 197 Ruijin 2nd Rd., Shanghai 200025, P. R. China. [6]Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Rd., Shanghai 200025, P. R. China. [7]Department of Plastic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, 16766 Jingshi Rd., Jinan 250014, Shandong, P. R. China. [8]Jinan Clinical Research Center for Tissue Engineering Skin Regeneration and Wound Repair, 16766 Jingshi Rd., Jinan 250014, Shangdong, P. R. China.
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