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Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Ma Shuai[1,5,6,8,24] * ; Ji Zhejun[2,5,6] * ; Zhang Bin[1,8] * ; Geng Lingling[7] * ; Cai Yusheng[1,5,6] * ; Nie Chao[9] * ; Li Jiaming[3,4,8] * ; Zuo Yuesheng[3,4,8] * ; Sun Yuzhe[12] * ; Xu Gang[11] * ; Liu Beibei[3,4] ; Ai Jiaqi[7] ; Liu Feifei[1,5,6,10] ; Zhao Liyun[7] ; Zhang Jiachen[7] ; Zhang Hui[1,8,10] ; Sun Shuhui[1,5,6,10] ; Huang Haoyan[7] ; Zhang Yiyuan[1,5,6] ; Ye Yanxia[2,5,6] ; Fan Yanling[3,4] ; Zheng Fangshuo[13] ; Hu Jinghao[7] ; Zhang Baohu[2,8] ; Li Jingyi[1,5,6,8] ; Feng Xin[14] ; Zhang Feng[15] ; Zhuang Yuan[16] ; Li Tianjie[17] ; Yu Yang[18] ; Bao Zhaoshi[19] ; Pan Sipei[20] ; Rodriguez Esteban Concepcion[21] ; Liu Zhili[9] ; Deng Haohao[12] ; Wen Feng[12] ; Song Moshi[1,5,6,8] ; Wang Si[7,24] ; Zhu Guodong[22] ; Yang Jiayin[11] ; Jiang Tao[19] ; Song Weihong[20] ; Izpisua Belmonte Juan Carlos[21] ; Qu Jing[2,5,6,8,10,24] ; Zhang Weiqi[3,4,8,24] ; Gu Ying[9,12,23] ; Liu Guang-Hui[1,5,6,7,8,24] ;
机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]China National Center for Bioinformation, Beijing, China [4]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China [5]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [6]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [7]National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, International Center for Aging and Cancer,Xuanwu Hospital Capital Medical University, Beijing 100053, China [8]University of Chinese Academy of Sciences, Beijing 100049, China [9]BGI Research, Shenzhen 518083, China [10]Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China [11]Liver Transplant Center, Organ Transplant Center, West China Hospital of Sichuan University, Chengdu 610000, China [12]BGI Research, Beijing 102601, China [13]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China [14]CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China [15]Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou 324000, China [16]Department of Blood Transfusion, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China [17]Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [18]Clinical Stem Cell Research Center, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China [19]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China [20]Oujiang Laboratory, Center for Geriatric Medicine and Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Zhejiang Provincial Clinical Research for Mental Disorders, The First-affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China [21]Altos Labs San Diego Institute of Science, San Diego, CA, USA [22]Institute of Gerontology, Guangzhou Geriatric Hospital, Guangzhou Medical University, Guangzhou, China [23]BGI Research, Hangzhou 310030, China [24]Aging Biomarker Consortium (ABC), Beijing 100101, China
出处：
DOI： 10.1016/j.cell.2024.10.019
ISSN：

摘要：
To systematically characterize the loss of tissue integrity and organ dysfunction resulting from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male mice during aging. We showed that senescence-sensitive spots (SSSs) colocalized with elevated entropy in organizational structure and that the aggregation of immunoglobulin-expressing cells is a characteristic feature of the microenvironment surrounding SSSs. Immunoglobulin G (IgG) accumulated across the aged tissues in both male and female mice, and a similar phenomenon was observed in human tissues, suggesting the potential of the abnormal elevation of immunoglobulins as an evolutionarily conserved feature in aging. Furthermore, we observed that IgG could induce a pro-senescent state in macrophages and microglia, thereby exacerbating tissue aging, and that targeted reduction of IgG mitigated aging across various tissues in male mice. This study provides a high-resolution spatial depiction of aging and indicates the pivotal role of immunoglobulin-associated senescence during the aging process.Copyright © 2024 Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (82125011, 82488301, 82322025, 81921006, and 82122024), the National Key Research and Development Program of China (2020YFA0804000, 2022YFA1103700, 2020YFA0112200, 2021YFF1201000, 2021YFA1101401, 2022YFA1103800, 2022YFC3602503, 2022YFA1104701, 2023YFC3504301, 2020YFA0113400, and the STI2030- Major Projects-2021ZD0202400), the National Natural Science Foundation of China (92149301, 92168201, 82330044, 32341001, 92049304, 92049116, 32121001, 82192863, 82361148131, 82271600, 32200610, 82371570, 82201727, 82301758, 32300980, 82071588, 82230043, 82361148130, and 8231101626), the CAS Project for Young Scientists in Basic Research (YSBR-076, YSBR-012, and YSBR-036), the CAS Youth Interdisciplinary Team, the Program of the Beijing Natural Science Foundation (Z230011, Z240018, JQ24044, and 5242024), Shenzhen Science and Technology Program (grant no. RCJC20221008092804002), the Informatization Plan of CAS (CAS-WX2022SDC-XK14), the New Cornerstone Science Foundation through the XPLORER PRIZE (2021-1045), the Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes (JYY2023-13), the Youth Innovation Promotion Association of CAS (E1CAZW0401, 2022083, 2023092, and 2020085), the Young Elite Scientists Sponsorship Program by CAST (2021QNRC001), the Initiative Scientific Research Program, the Institute of Zoology, the CAS (2023IOZ0102 and 2023IOZ0202), the Beijing Nova Program (20240484493), the Excellent Young Talents Program of Capital Medical University (12300927), the Key Laboratory of Alzheimer’s Disease of Zhejiang Province (ZJAD-2024001), the Project for Technology Development of Beijing-Affiliated Medical Research Institutes (11000023T000002036310), and the Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team (BPHR202203105).
语种：
外文
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出版当年[2024]版：
无
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [5]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [6]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [8]University of Chinese Academy of Sciences, Beijing 100049, China [24]Aging Biomarker Consortium (ABC), Beijing 100101, China
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]China National Center for Bioinformation, Beijing, China [4]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China [5]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [6]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [7]National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, International Center for Aging and Cancer,Xuanwu Hospital Capital Medical University, Beijing 100053, China [8]University of Chinese Academy of Sciences, Beijing 100049, China [9]BGI Research, Shenzhen 518083, China [10]Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China [12]BGI Research, Beijing 102601, China [23]BGI Research, Hangzhou 310030, China [24]Aging Biomarker Consortium (ABC), Beijing 100101, China
推荐引用方式(GB/T 7714)：
Ma Shuai,Ji Zhejun,Zhang Bin,et al.Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging[J].Cell.2024,187(24):7025-7044.e34.doi:10.1016/j.cell.2024.10.019.
APA：
Ma Shuai,Ji Zhejun,Zhang Bin,Geng Lingling,Cai Yusheng...&Liu Guang-Hui.(2024).Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging.Cell,187,(24)
MLA：
Ma Shuai,et al."Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging".Cell 187..24(2024):7025-7044.e34

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