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Methylation modification is a poor prognostic factor in non-small cell lung Cancer and regulates the tumor microenvironment: mRNA molecular structure and function

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资源类型：
Pubmed体系：
作者：
Yang Kai[1,2,3,4] * ; Yang YuPing[1,2,3] * ; Yu Lin[1,2,3] * ; Yang Fan[1,2,3] ; Xiang YuXin[3] ; Zeng Jun[1,2,3] ; Huang Na[1,2,3] ;
机构： [1]Key Laboratory of Geriatic Respiratory Diseases of Sichuan Higher Education Institute, Chengdu, Sichuan, China [2]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital Of Chengdu Medical College, Chengdu, Sichuan, China [3]School Of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China [4]Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
出处：
DOI： 10.1016/j.ijbiomac.2024.137214
ISSN：

关键词： Methylation modification Non-small cell lung cancer Prognostic regulation Adverse factors Tumor microenvironment mRNA molecular structure

摘要：
Non-small cell lung cancer (NSCLC) is the most common and deadly type of lung cancer, and its poor prognosis is closely related to the complex interactions of the tumor microenvironment. Through methylation analysis of tumor tissue samples from NSCLC patients, combined with high-throughput sequencing technology, the methylation status and structural characteristics of mRNA molecules were studied. Bioinformatics tools were used to analyze the regulatory effects of methylation modification on mRNA expression and genes associated with the tumor microenvironment. The results showed that the methylation level of specific mRNA was significantly correlated with the expression changes of tumor microenvironment-related factors. In addition, methylation modification affected mRNA stability and translation efficiency, further altering the metabolic activity and immune escape capacity of tumor cells. The results showed that mRNA with high methylation level was significantly associated with poor prognosis. Methylation modification profoundly affects the tumor microenvironment and prognosis of non-small cell lung cancer by altering the structure and function of mRNA molecules.Copyright © 2024 Elsevier B.V. All rights reserved.

基金：
Science & Technology Department of Sichuan Province (2022NSFSC0725), Sichuan Anti-Cancer Association (XH2023033), Health Commission of Sichuan Province (2024-2301),Chengdu Medical College (CYZYB23-23).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
第一作者：
第一作者机构： [1]Key Laboratory of Geriatic Respiratory Diseases of Sichuan Higher Education Institute, Chengdu, Sichuan, China [2]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital Of Chengdu Medical College, Chengdu, Sichuan, China [3]School Of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China [4]Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Geriatic Respiratory Diseases of Sichuan Higher Education Institute, Chengdu, Sichuan, China [2]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital Of Chengdu Medical College, Chengdu, Sichuan, China [3]School Of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Yang Kai,Yang YuPing,Yu Lin,et al.Methylation modification is a poor prognostic factor in non-small cell lung Cancer and regulates the tumor microenvironment: mRNA molecular structure and function[J].International Journal Of Biological Macromolecules.2024,282(Pt 4):137214.doi:10.1016/j.ijbiomac.2024.137214.
APA：
Yang Kai,Yang YuPing,Yu Lin,Yang Fan,Xiang YuXin...&Huang Na.(2024).Methylation modification is a poor prognostic factor in non-small cell lung Cancer and regulates the tumor microenvironment: mRNA molecular structure and function.International Journal Of Biological Macromolecules,282,(Pt 4)
MLA：
Yang Kai,et al."Methylation modification is a poor prognostic factor in non-small cell lung Cancer and regulates the tumor microenvironment: mRNA molecular structure and function".International Journal Of Biological Macromolecules 282..Pt 4(2024):137214

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