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Ultrasound-triggered and glycosylation inhibition-enhanced tumor piezocatalytic immunotherapy

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机构： [1]Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China. [2]Central Laboratory and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072 Sichuan, P. R. China. [3]Department of Radiology, The First Affiliated Hospital,College ofMedicine, Zhejiang University, Hangzhou 310003 Zhejiang, P. R. China. [4]Digestive endoscopy center, Shanghai Fourth People’s Hospital to Tongji University, Shanghai 200081, P. R. China

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Nanocatalytic immunotherapy holds excellent potential for future cancer therapy due to its rapid activation of the immune system to attack tumor cells. However, a high level of N-glycosylation can protect tumor cells, compromising the anticancer immunity of nanocatalytic immunotherapy. Here, we show a 2-deoxyglucose (2-DG) and bismuth ferrite co-loaded gel (DBG) scaffold for enhanced cancer piezocatalytic immunotherapy. After the implantation in the tumor, DBG generates both reactive oxygen species (ROS) and piezoelectric signals when excited with ultrasound irradiation, significantly promoting the activation of anticancer immunity. Meanwhile, 2-DG released from ROS-sensitive DBG disrupts the N-glycans synthesis, further overcoming the immunosuppressive microenvironment of tumors. The synergy effects of ultrasound-triggered and glycosylation inhibition enhanced tumor piezocatalytic immunotherapy are demonstrated on four mouse cancer models. A "hot" tumor-immunity niche is produced to inhibit tumor progress and lung metastasis and elicit strong immune memory effects. This work provides a promising piezocatalytic immunotherapy for malignant solid tumors featuring both low immunogenicity and high levels of N-glycosylation.© 2024. The Author(s).

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大类 | 1 区

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Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 14.7 最新[2023版] 16.1 最新五年平均 14.7 出版当年[2023版] 0 出版当年五年平均 14.7 出版前一年[2023版]

第一作者：

第一作者机构： [1]Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China. [2]Central Laboratory and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072 Sichuan, P. R. China.

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通讯作者：

通讯机构： [1]Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China. [2]Central Laboratory and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072 Sichuan, P. R. China.

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