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Fe-HCOF-PEG2000 as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy

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资源类型：
Pubmed体系：
作者：
Peng Hui[1,2] * ; Jiang Qian[1] * ; Mao Wenhao[1,3] * ; Hu Zhonglan[1] * ; Wang Qi[4] ; Yu Zhuo[1] ; Zhang Li[1] ; Wang Xinyan[5] ; Zhuang Chunbo[1] ; Mai Jia[6] ; Wang Zhiyuan[7] ; Sun Ting[1] ;
机构： [1]Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China. [2]Center for Clinical Laboratory, General Hospital of the Yangtze River Shipping Wuhan Brain Hospital, Wuhan, Hubei, 430010, People's Republic of China. [3]Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China. [4]Department of Pharmacy, Kaifeng Hospital of Traditional Chinese Medicine, Kaifeng, 475000, People's Republic of China. [5]Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China. [6]Department of Laboratory Medicine, West China Second Hospital, Sichuan University, Chengdu, 610041, People's Republic of China. [7]Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
出处：
DOI： 10.2147/IJN.S479848
ISSN：

关键词： HCOFs PDT ROS hypoxia ferroptosis cancer cells

摘要：
The hypoxic tumor microenvironment and single mechanisms severely limit the photodynamic therapy (PDT) efficiency of covalent organic framework (COF) nanoparticles in cancer treatment.Here, we propose an iron-loaded, hydrophilic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000)-modified hollow covalent organic framework (HCOF), Fe-HCOF-PEG2000, for use in hypoxic PDT and ferroptosis therapy owing to its type I and II photodynamic ability and iron nanoparticle loading property.Fe-HCOF-PEG2000 nanoparticles (Fe-HCOFs-PEG2000) with semiconducting polymers and microporous skeletons allow efficient photophysical properties. Moreover, the iron nanoparticles on Fe-HCOF-PEG2000 caused ferroptosis and further enhanced tumor elimination under normoxic and hypoxic conditions. DSPE-PEG2000 endowed Fe-HCOF-PEG2000 with hydrophilicity, allowing it to circulate and accumulate in organs rich in blood supply, especially tumors. 808 nm NIR activated Fe-HCOF-PEG2000 aggregated in tumors and significantly inhibited tumor growth under hypoxia.To our knowledge, Fe-HCOF-PEG2000 is the leading combination of type I/II PDT and ferroptosis. The strong antitumor effects of this nanomaterial suggest prospects for clinical translation as a tumor nanotherapy drug.© 2024 Peng et al.

基金：
The authors acknowledge the financial support from National Natural Science Foundation of China (81874188); Outstanding Youth Foundation of Henan Province (222300420071); Fund for Distinguished Young Scholars of medical science and technology innovation in Henan Province (YXKC2022033); Fund for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University (QNCXTD2023018); Postdoctoral Science Foundation of China (2022T150554); Postdoctoral Science Foundation of Henan Province (202102079).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 纳米科技
第一作者：
第一作者机构： [1]Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China. [2]Center for Clinical Laboratory, General Hospital of the Yangtze River Shipping Wuhan Brain Hospital, Wuhan, Hubei, 430010, People's Republic of China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Peng Hui,Jiang Qian,Mao Wenhao,et al.Fe-HCOF-PEG2000 as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy[J].International Journal Of Nanomedicine.2024,19:10165-10183.doi:10.2147/IJN.S479848.
APA：
Peng Hui,Jiang Qian,Mao Wenhao,Hu Zhonglan,Wang Qi...&Sun Ting.(2024).Fe-HCOF-PEG2000 as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy.International Journal Of Nanomedicine,19,
MLA：
Peng Hui,et al."Fe-HCOF-PEG2000 as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy".International Journal Of Nanomedicine 19.(2024):10165-10183

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