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Organoid modeling meets cancers of female reproductive tract

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机构: [1]Translational Chinese Medicine Key Laboratory of Sichuan, Sichuan-Chongqing Joint Key Laboratory of Innovation of New Drugs of Traditional Chinese Medicine, Sichuan Institutefor Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China [2]West China School of Pharmacy, Sichuan University, Chengdu, China [3]School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China [4]Information Technology Center, West China Hospital of Sichuan University, SichuanUniversity, Chengdu, China [5]Chongqing Medical University, Chongqing, China [6]Rehabilitation Department, Changgeng Yining Hospital, Wenzhou, China [7]Geriatric Department,Changgeng Yining Hospital, Wenzhou, China [8]Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA [9]Department of RadiationOncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China
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Diseases of the female reproductive system, especially malignant tumors, pose a serious threat to women's health worldwide. One of the key factors limiting research progress in this area is the lack of representative models. Organoid technology, especially tumor organoids, has been increasingly applied in the study of female reproductive system tumors due to their high heterogeneity, close resemblance to the physiological state, easy acquisition and cultivation advantages. They play a significant role in understanding the origin and causes of tumors, drug screening, and personalized treatment and more. This article reviews the organoid models for the female reproductive system, focusing on the cancer research advancements. It discusses the methods for constructing tumor organoids of the female reproductive tract and summarizes the limitations of current research. The aim is to offer a reference for future development and application of these organoid models, contributing to the advancement of anti-tumor drugs and treatment strategies for female reproductive tract cancer patients.© 2024. The Author(s).

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大类 | 2 区 生物学
小类 | 2 区 细胞生物学
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Q1 CELL BIOLOGY

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第一作者机构: [1]Translational Chinese Medicine Key Laboratory of Sichuan, Sichuan-Chongqing Joint Key Laboratory of Innovation of New Drugs of Traditional Chinese Medicine, Sichuan Institutefor Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China [2]West China School of Pharmacy, Sichuan University, Chengdu, China
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