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Tracking Peripheral Memory T Cell Subsets in Advanced Nonsmall Cell Lung Cancer Treated with Hypofractionated Radiotherapy and PD-1 Blockade

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机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, China. [2]Public Center of Experimental Technology, The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan Province 646000, China. [3]Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, China. [4]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Institute of Neclear Medicine, Southwest Medical Universty, Luzhou 646000, China. [5]Academician (Expert) Workstation of Sichuan Province, Sichuan, Luzhou, China.

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Hypofractionated radiotherapy (HFRT) or chemotherapy combined with programmed death-1 (PD-1) blockade has achieved good clinical control in advanced nonsmall cell lung cancer (NSCLC). However, the relative influence of HFRT + PD-1 blockade and chemo-immunotherapy on peripheral memory T cell subsets in NSCLC responders has not been evaluated in clinical practice. Thirty-nine patients with advanced NSCLC were enrolled. The frequencies of naive (Tn; CD45RA+CCR7+), central memory (Tcm; CD45RA-CCR7+), effector memory (Tem; CD45RA-CCR7-), and effector memory RA (TemRA; CD45RA+CCR7-) T cell subsets and PD-1 expression were analyzed in CD4+ and CD8+ T cells using flow cytometry from peripheral blood samples. The correlations of memory T cell subsets and PD-1 expression with overall survival in HFRT + PD-1 blockade group were examined using the Kaplan-Meier method. Patients with partial response to HFRT + PD-1 blockade showed reduction in Tn and expansion in TemRA cell subpopulations among CD8+ T cells and reduced PD-1+CD4+ and PD-1+CD8+ T cells, all of which were significantly correlated with overall survival. The responders to chemo-immunotherapy showed expansion of the TemRA and decrease of Tcm in CD8+ T cell subpopulation. Our findings show that HFRT+PD-1 blockade and chemo-immunotherapy combination therapies induce differential memory T cell subset differentiation, offering predictive markers for treatment response. Clinical Trial Information: https://clinicaltrials.gov/ct2/show/ChiCTR-1900027768.Copyright © 2023 Pengyuan Kang et al.

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第一作者机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, China. [2]Public Center of Experimental Technology, The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan Province 646000, China.

通讯作者：

通讯机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 646000, China. [2]Public Center of Experimental Technology, The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan Province 646000, China. [4]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Institute of Neclear Medicine, Southwest Medical Universty, Luzhou 646000, China. [5]Academician (Expert) Workstation of Sichuan Province, Sichuan, Luzhou, China.

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