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Sex disparities of clinical manifestations in acute pulmonary embolism and predictive value for in-hospital mortality: Insights from CURES

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收录情况： ◇ SCIE

作者：
Han Tian[a,b] * ; Yu Zhang[b,c] ; JiXiang Liu[b] ; Yuanhua Yang[d] ; Yingqun Ji[e] ; Hong Chen[f] ; Dingyi Wang[b,g] ; Zhu Zhang[b] ; Qun Yi[h] ; Chunling Dong[i] ; Xiaomao Xu[j] ; Xiaoyun Hu[k] ; Yimin Mao[l] ; Ling Zhu[m] ; Zhihong Liu[n] ; Juhong Shi[o] ; Chaosheng Deng[p] ; Zhe Cheng[q] ; Yunxia Zhang[b] ; Meng Zhang[r] ; Wenyi Pang[s] ; Jieping Lei[b,g] ; Sinan Wu[b,g] ; Yuzhi Tao[t] ; Linfeng Xi[b,c] ; Qian Gao[b] ; Shuai Zhang[b] ; Chaozeng Si[u] ; Lei Xia[v] ; Min Liu[w] ; Aili Li[x] ; Yihong Sun[x] ; Qiang Huang[b] ; Wanmu Xie[b] ; Jun Wan[r] ; Peiran Yang[y] ; Shengfeng Wang[z] ; Chen Wang[a,b] ; Zhenguo Zhai[a,b] ;
机构： [a]China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China [b]National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China- Japan Friendship Hospital, Beijing, China [c]China-Japan Friendship Hospital, Capital Medical University, Beijing, China [d]Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China [e]Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, Shanghai, China [f]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [g]Data and Project Management Unit, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China [h]Sichuan Cancer Hospital, Chengdu, China [i]Department of Pulmonary and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China [j]Department of Pulmonary and Critical Care Medicine, Beijing Hospital, Beijing, China [k]Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi Medical University, Taiyuan, China [l]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China [m]Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China [n]Fuwai Hospital, Chinese Academy of Medical Science, National Center for Cardiovascular Diseases, Beijing, China [o]Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China [p]Department of Pulmonary and Critical Care Medicine, The first affiliated Hospital of Fujian Medical University, Fuzhou, China [q]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [r]Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China [s]Department of Pulmonary and Critical Care Medicine, Beijing Jishuitan Hospital, Fourth Medical College of Peking University, Beijing, China [t]The First Bethune Hospital of Jilin University, Changchun, China [u]Department of Information Management, China-Japan Friendship Hospital, Beijing, China [v]Medical Affairs Department of China-Japan Friendship Hospital, Beijing, China [w]Department of Radiology, China-Japan Friendship Hospital, Beijing, China [x]Department of Cardiology, China-Japan Friendship Hospital, Beijing, China [y]State Key Laboratory of Respiratory Health and Multimorbidity, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China [z]Department of Epidemiology & Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China
出处：
DOI： 10.1016/j.thromres.2024.109146
ISSN：

关键词： Pulmonary embolism Sex disparities In-hospital mortality Clinical manifestation Hemoptysis

摘要：
Pulmonary embolism (PE) is a common and potentially fatal disease, with differences in mortality rates among PE patients of different sexes. This study aims to investigate the disparities in clinical manifestations and in-hospital mortality rates between sexes in PE patients, as well as the association of clinical symptoms with in-hospital mortality.We analyzed data from the China pUlmonary thromboembolism REgistry Study (CURES), a nationwide, multicenter, prospective registry focusing on patients with acute PE. Using propensity score matching (PSM) to pair male and female patients with PE, we explored the correlation between clinical symptoms and in-hospital mortality through multivariable regression analysis.A total of 15,203 patients with acute PE were enrolled, and 380 died during hospitalization. The incidence of chest pain, hemoptysis, and palpitations was significantly higher in males compared to females. The incidence of dyspnea, fever, and syncope was higher in females. Hemoptysis and dyspnea were associated with increased in-hospital mortality in males, whereas dyspnea, fever, and palpitations were linked to higher mortality in females. Overall, males exhibited a higher in-hospital mortality than females (2.9 % vs. 2.1 %, p = 0.002). After matching 13,130 patients using the PSM method, the mortality rate of males remained higher than that of females (2.7 % vs. 2.1 %, p = 0.020).Our study demonstrates that male patients with PE have a higher risk of in-hospital mortality than females. Significant differences in clinical symptoms between sexes are associated with increased mortality risk, emphasizing the need for clinical awareness.Copyright © 2024. Published by Elsevier Ltd.

基金：
This work was supported by CAMS Innovation Fund for Medical Sciences (CIFMS) (No. 2021-I2M-1-061), CAMS Innovation Fund for Medical Sciences (CIFMS) (No. 2021-I2M-1-049), National Key Research and Development Program of China (No. 2023YFC2507201), National High Level Hospital Clinical Research Funding (No. 2022-NHLHCRF-LX- 01), National Natural Science Foundation of China (No. 82241029).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 血液学 3 区 外周血管病
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 HEMATOLOGY Q1 PERIPHERAL VASCULAR DISEASE

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [a]China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China [b]National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China- Japan Friendship Hospital, Beijing, China
通讯作者：
通讯机构： [a]China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China [b]National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China- Japan Friendship Hospital, Beijing, China
推荐引用方式(GB/T 7714)：
Han Tian,Yu Zhang,JiXiang Liu,et al.Sex disparities of clinical manifestations in acute pulmonary embolism and predictive value for in-hospital mortality: Insights from CURES[J].Thrombosis Research.2024,243:109146.doi:10.1016/j.thromres.2024.109146.
APA：
Han Tian,Yu Zhang,JiXiang Liu,Yuanhua Yang,Yingqun Ji...&Zhenguo Zhai.(2024).Sex disparities of clinical manifestations in acute pulmonary embolism and predictive value for in-hospital mortality: Insights from CURES.Thrombosis Research,243,
MLA：
Han Tian,et al."Sex disparities of clinical manifestations in acute pulmonary embolism and predictive value for in-hospital mortality: Insights from CURES".Thrombosis Research 243.(2024):109146

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