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Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine

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机构： [1]Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, China. [2]Department of Model Worker and Innovative Craftsman, West China Hospital, Sichuan University, Chengdu 610064, China.

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关键词： osteosarcoma models cell lines 3D culture technology mice models canine models drug discovery

摘要：

The management of osteosarcoma (OS) patients presents a significant clinical challenge. Despite progress in conventional and targeted therapies, the survival rate of OS patients remains limited largely due to therapy resistance and the high metastatic potential of the disease. OS models that accurately reflect the fundamental characteristics are vital to the innovation and validation of effective therapies. This review provides an insight into the advances and challenges in OS drug development, focusing on various preclinical models, including cell lines, 3D culture models, murine models, and canine models. The relevance, strengths, and limitations of each model in OS research are explored. In particular, we highlight a range of potential therapeutics identified through these models. These instances of successful drug development represent promising pathways for personalized OS treatment.

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出版当年[2023]版：

大类 | 2 区生物学

小类 | 3 区生化与分子生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 3 区生化与分子生物学

第一作者：

第一作者机构： [1]Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, China. [2]Department of Model Worker and Innovative Craftsman, West China Hospital, Sichuan University, Chengdu 610064, China.

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通讯作者：

通讯机构： [1]Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, China. [2]Department of Model Worker and Innovative Craftsman, West China Hospital, Sichuan University, Chengdu 610064, China.

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