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Shaping the future of gastrointestinal cancers through metabolic interactions with host gut microbiota

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资源类型：
Pubmed体系：
作者：
Xie Wen[1] * ; Sharma Aditi[2] * ; Kaushik Hitesh[2] ; Sharma Lalit[2] ; Nistha[2] ; Anwer Md Khalid[3] ; Sachdeva Monika[4] ; Elossaily Gehan M[5] ; Zhang Yingbo[6] ; Pillappan Ramkumar[7] ; Kaur Maninderjit[8] ; Behl Tapan[9] ; Shen Bairong[1] ; Singla Rajeev K[1,10,*1] ;
机构： [1]Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. [2]School of Pharmaceutical Sciences, Shoolini University, Solan, H.P, 173229, India. [3]Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia. [4]Fatima College of Health Sciences, Al Ain, United Arab Emirates. [5]Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh, 11597, Saudi Arabia. [6]Institutes for Systems Genetics, West China Tianfu Hospital, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, 610218, China. [7]Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences, Mangaluru, Karnataka, India. [8]Department of Pharmaceutical Sciences, lovely Professional University, Phagwara, India. [9]Amity School of Pharmaceutical Sciences, Amity University, Sahibzada Ajit Singh Nagar, Punjab, India. [10]School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 1444411, India.
出处：
DOI： 10.1016/j.heliyon.2024.e35336
ISSN：

关键词： Gastrointestinal cancers Microbiome research Metabolic interplay Precision diagnosis Therapeutic approaches Microbiome

摘要：
Gastrointestinal (GI) cancers represent a significant global health challenge, driving relentless efforts to identify innovative diagnostic and therapeutic approaches. Recent strides in microbiome research have unveiled a previously underestimated dimension of cancer progression that revolves around the intricate metabolic interplay between GI cancers and the host's gut microbiota. This review aims to provide a comprehensive overview of these emerging metabolic interactions and their potential to catalyze a paradigm shift in precision diagnosis and therapeutic breakthroughs in GI cancers. The article underscores the groundbreaking impact of microbiome research on oncology by delving into the symbiotic connection between host metabolism and the gut microbiota. It offers valuable insights into tailoring treatment strategies to individual patients, thus moving beyond the traditional one-size-fits-all approach. This review also sheds light on novel diagnostic methodologies that could transform the early detection of GI cancers, potentially leading to more favorable patient outcomes. In conclusion, exploring the metabolic interactions between host gut microbiota and GI cancers showcases a promising frontier in the ongoing battle against these formidable diseases. By comprehending and harnessing the microbiome's influence, the future of precision diagnosis and therapeutic innovation for GI cancers appears more optimistic, opening doors to tailored treatments and enhanced diagnostic precision.© 2024 The Authors.

基金：
This work was supported by the National Natural Science Foundation of China (32070671, 32270690).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
第一作者：
第一作者机构： [1]Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. [10]School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 1444411, India. [*1]Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
推荐引用方式(GB/T 7714)：
Xie Wen,Sharma Aditi,Kaushik Hitesh,et al.Shaping the future of gastrointestinal cancers through metabolic interactions with host gut microbiota[J].Heliyon.2024,10(15):e35336.doi:10.1016/j.heliyon.2024.e35336.
APA：
Xie Wen,Sharma Aditi,Kaushik Hitesh,Sharma Lalit,Nistha...&Singla Rajeev K.(2024).Shaping the future of gastrointestinal cancers through metabolic interactions with host gut microbiota.Heliyon,10,(15)
MLA：
Xie Wen,et al."Shaping the future of gastrointestinal cancers through metabolic interactions with host gut microbiota".Heliyon 10..15(2024):e35336

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