机构:[1]Sichuan Univ, West China Univ Hosp 2, Evidence based Pharm Ctr, Dept Pharm,Childrens Med Key Lab Sichuan Prov, Chengdu 610041, Peoples R China[2]Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Peoples R China[3]Sichuan Univ, West China Univ Hosp 2, Dept Gynecol & Obstet, Dev & Related Dis Women, Chengdu 610041, Peoples R China[4]Sichuan Univ, West China Univ Hosp 2, Children Key Lab Sichuan Prov, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu 610041, Peoples R China[5]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Inst Lab Med, Sch Med, Chengdu 610072, Peoples R China四川省人民医院[6]Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China[7]Sichuan Univ, West China Hosp, West China Med Sch, Dept Neurosurg, Chengdu 610041, Peoples R China四川大学华西医院[8]Sichuan Univ, West China Hosp, Inst Neurosurg, State Key Lab Biotherapy & Canc Ctr, Chengdu 610041, Peoples R China四川大学华西医院[9]Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engineered nanoparticles can be employed as contrast agents in cancer diagnostics to enable high sensitivity and high-resolution tumor detection by imaging examinations. Novel approaches for tumor labeling and detection are also made possible by the use of nanoprobes and nanobiosensors. The achievement of targeted medication delivery in cancer therapy can be accomplished through the rational design and manufacture of nanodrug carriers. Nanoparticles have the capability to effectively transport medications or gene fragments to tumor tissues via passive or active targeting processes, thus enhancing treatment outcomes while minimizing harm to healthy tissues. Simultaneously, nanoparticles can be employed in the context of radiation sensitization and photothermal therapy to enhance the therapeutic efficacy of malignant tumors. This review presents a literature overview and summary of how nanotechnology is used in the diagnosis and treatment of malignant tumors. According to oncological diseases originating from different systems of the body and combining the pathophysiological features of cancers at different sites, we review the most recent developments in nanotechnology applications. Finally, we briefly discuss the prospects and challenges of nanotechnology in cancer.
基金:
National Natural Science Foundation of China, China [82172643, 32222046, 32371545]; Sichuan Science and Technology Program, China [2023NSFSC1931]; The 1<middle dot>3<middle dot>5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, China [ZYJC21022]
第一作者机构:[1]Sichuan Univ, West China Univ Hosp 2, Evidence based Pharm Ctr, Dept Pharm,Childrens Med Key Lab Sichuan Prov, Chengdu 610041, Peoples R China[2]Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[7]Sichuan Univ, West China Hosp, West China Med Sch, Dept Neurosurg, Chengdu 610041, Peoples R China[8]Sichuan Univ, West China Hosp, Inst Neurosurg, State Key Lab Biotherapy & Canc Ctr, Chengdu 610041, Peoples R China[9]Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China
推荐引用方式(GB/T 7714):
Wang Bilan,Hu Shiqi,Teng Yan,et al.Current advance of nanotechnology in diagnosis and treatment for malignant tumors[J].SIGNAL TRANSDUCTION AND TARGETED THERAPY.2024,9(1):doi:10.1038/s41392-024-01889-y.
APA:
Wang, Bilan,Hu, Shiqi,Teng, Yan,Chen, Junli,Wang, Haoyuan...&Gao, Xiang.(2024).Current advance of nanotechnology in diagnosis and treatment for malignant tumors.SIGNAL TRANSDUCTION AND TARGETED THERAPY,9,(1)
MLA:
Wang, Bilan,et al."Current advance of nanotechnology in diagnosis and treatment for malignant tumors".SIGNAL TRANSDUCTION AND TARGETED THERAPY 9..1(2024)