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PD-L1 expression and its correlation with tumor biomarkers in Chinese urothelial bladder cancer

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机构： [1]Department of Urology, Peking University First Hospital, Beijing 100034, China. [2]Department of Urology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Changsha 410006, China. [3]Department of Urology, Zhejiang Provincial People’s Hospital, Hangzhou 310005, Zhejiang, China. [4]Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210000, Jiangsu, China. [5]Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. [6]Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. [7]Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiafang Avenue, Qiaokou, Wuhan 430000, Hubei, China. [8]Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Science, Beijing 100005, China. [9]Department of Urology, First Hospital of Jilin University, Changchun 130000, Jilin, China. [10]Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200040, China. [11]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. [12]Department of Urology, Meizhou People’s Hospital, Meizhou 514031, Guangdong, China. [13]Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian, China. [14]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. [15]Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China. [16]Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510000, China. [17]Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

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关键词： Immune cells Muscle-invasive urothelial bladder cancer Prevalence of PD-L1 expression Tumor biomarkers Tumor cells Tumor mutation burden

摘要：

Data on prevalence of programmed death ligand-1 (PD-L1) expression and its correlation with tumor biomarkers in Chinese patients with muscle-invasive urothelial bladder cancer (MIUBC) are scarce. We investigated the prevalence of PD-L1 expression, PD-L1 expression in tumor cells (TC) and immune cells (IC), and its correlation with tumor biomarkers (CD8+ T cells and tumor mutation burden [TMB]) in Chinese patients with newly diagnosed MIUBC (NCT03433924). Of 248 patients enrolled, 229 with PD-L1 data available were analysed. High PD-L1 expression (≥ 25% of TC or IC with PD-L1 expression) was observed in 120 (52.4%) patients. 59 cases showed positive staining in ≥ 25% of TC, and 82 cases had positive staining in ≥ 25% of IC. High expression of CD8+ T cell and TMB (> 10 mutations/megabase) was observed in 44.5% and 54.1% patients, respectively. A positive correlation was observed between percentage of TC with membrane PD-L1 positivity and CD8+ T cells (0.34; P < 0.001) and between IC with membrane PD-L1 positivity and CD8+ T cells (0.44; P < 0.001). There is high prevalence of PD-L1 expression in Chinese patients with MIUBC, suggesting that a sizable subset of patients could benefit from immunotherapy. The correlation of PD-L1 expression with tumor biomarkers provide clues for mechanisms underlying the effects of biomarkers for predicting efficacy.© 2024. The Author(s).

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大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

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Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.8 最新[2023版] 4.3 最新五年平均 3.8 出版当年[2023版] 0 出版当年五年平均 3.8 出版前一年[2023版]

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第一作者机构： [1]Department of Urology, Peking University First Hospital, Beijing 100034, China.

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PD-L1 expression and its correlation with tumor biomarkers in Chinese urothelial bladder cancer

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