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TMEM52B Isoforms P18 and P20 Differentially Promote the Oncogenesis and Metastasis of Nasopharyngeal Carcinoma

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收录情况： ◇ SCIE

作者：
Zhu Yuqi[1,2,3] * ; Lu Yanxin[1,4] * ; Xu Chunhua[1,2] * ; Huang Yuqian[1] * ; Yu Ziyi[1] ; Wang Tongyu[1] ; Mao Longyi[1] ; Liao Ximian[1] ; Li Shi[1] ; Zhang Wanqing[1] ; Zhou Feng[5] ; Liu Kaiqing[1] ; Zhang Yu[1,2] ; Yang Wei[1,2] ; Min Shasha[1,4] ; Deng Yaqin[1] ; Wang Zaixing[6] ; Fan Xiaoqin[7] ; Nie Guohui[7] ; Xie Xina[1] ; Li Zesong[1,3,4,8] ;
机构： [1]Guangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Key Laboratory of Genitourinary Tumor, Department of Urology, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518000, China. [2]Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, 518060, China. [3]Medical Research Center, The Affiliated Yue Bei People's Hospital, Shantou University Medical College, Shaoguan, 512025, China. [4]Basic Medical Science Department, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. [5]Oncology Department, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518060, China. [6]Institute of Otorhinolaryngology and Shenzhen Key of Otorhinolaryngology, Longgang Otorhinolaryngology Hospital, Shenzhen, 518172, China. [7]The Bio-bank of Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, 518000, China. [8]Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637199, China.
出处：
DOI： 10.1002/advs.202402457
ISSN：

关键词： E-cadherin metastasis nasopharyngeal carcinoma (NPC) phosphoglycerate kinase 1 (PGK1) TMEM52B isoforms

摘要：
Transmembrane protein 52B (TMEM52B), a newly identified tumor-related gene, has been reported to regulate various tumors, yet its role in nasopharyngeal carcinoma (NPC) remains unclear. Transcriptomic analysis of NPC cell lines reveals frequent overexpression of TMEM52B, and immunohistochemical results show that TMEM52B is associated with advanced tumor stage, recurrence, and decreased survival time. Depleting TMEM52B inhibits the proliferation, migration, invasion, and oncogenesis of NPC cells in vivo. TMEM52B encodes two isoforms, TMEM52B-P18 and TMEM52B-P20, differing in their N-terminals. While both isoforms exhibit similar pro-oncogenic roles and contribute to drug resistance in NPC, TMEM52B-P20 differentially promotes metastasis. This functional discrepancy may be attributed to their distinct subcellular localization; TMEM52B-P18 is confined to the cytoplasm, while TMEM52B-P20 is found both at the cell membrane and in the cytoplasm. Mechanistically, cytoplasmic TMEM52B enhances AKT phosphorylation by interacting with phosphoglycerate kinase 1 (PGK1), fostering NPC growth and metastasis. Meanwhile, membrane-localized TMEM52B-P20 promotes E-cadherin ubiquitination and degradation by facilitating its interaction with the E3 ubiquitin ligase NEDD4, further driving NPC metastasis. In conclusion, the TMEM52B-P18 and TMEM52B-P20 isoforms promote the metastasis of NPC cells through different mechanisms. Drugs targeting these TMEM52B isoforms may offer therapeutic benefits to cancer patients with varying degrees of metastasis.© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.

基金：
This research was funded by the National Natural Science Foundation of China (81972366, 82100706, and 82103523), the Natural Science Foundation of Guangdong Province (2022A1515012606), and the Science, Technology and Innovation Commission of Shenzhen Municipality (KCXFZ20211020164005007 and JCYJ20220818101808018).
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出版当年[2024]版：
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大类 | 1 区 材料科学
小类 | 1 区 化学：综合 1 区 材料科学：综合 2 区 纳米科技
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出版当年[2024]版：
无
最新[2023]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Guangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Key Laboratory of Genitourinary Tumor, Department of Urology, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518000, China. [2]Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, 518060, China. [3]Medical Research Center, The Affiliated Yue Bei People's Hospital, Shantou University Medical College, Shaoguan, 512025, China.
共同第一作者：
通讯作者：
通讯机构： [1]Guangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Key Laboratory of Genitourinary Tumor, Department of Urology, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518000, China. [3]Medical Research Center, The Affiliated Yue Bei People's Hospital, Shantou University Medical College, Shaoguan, 512025, China. [4]Basic Medical Science Department, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. [8]Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637199, China.
推荐引用方式(GB/T 7714)：
Zhu Yuqi,Lu Yanxin,Xu Chunhua,et al.TMEM52B Isoforms P18 and P20 Differentially Promote the Oncogenesis and Metastasis of Nasopharyngeal Carcinoma[J].ADVANCED SCIENCE.2024,e2402457.doi:10.1002/advs.202402457.
APA：
Zhu Yuqi,Lu Yanxin,Xu Chunhua,Huang Yuqian,Yu Ziyi...&Li Zesong.(2024).TMEM52B Isoforms P18 and P20 Differentially Promote the Oncogenesis and Metastasis of Nasopharyngeal Carcinoma.ADVANCED SCIENCE,,
MLA：
Zhu Yuqi,et al."TMEM52B Isoforms P18 and P20 Differentially Promote the Oncogenesis and Metastasis of Nasopharyngeal Carcinoma".ADVANCED SCIENCE .(2024):e2402457

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