机构：[1]Department of Ultrasound, Institute of Ultrasound Teaching and Research, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.[2]Department of Radiology, Institute of Radiation and Therapy, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.[3]Institute of Nanomedicine Innovation Research and Transformation, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
The rapid growth of research on enzyme-mimetic catalysts (Enz-Cats) is expected to promote further advances in nanomedicine for biological detection, diagnosis and treatment of disease, especially tumors. ROS-based nanomedicines present fascinating potential in antitumor therapy owing to the rapid development of nanotechnology. In this review, we focus on the applications of Enz-Cats based on ROS in antitumor therapy. Firstly, the definition and category of ROS are introduced, and the key factors enhancing ROS levels are carefully elucidated. Then, the rationally engineered Enz-Cats via different synthetic approaches with high ROS-producing efficiencies are comprehensively discussed. Subsequently, oncotherapy application of Enz-Cats is comprehensively discussed, which integrates diverse synergistic treatment modalities and exhibits high efficiency in ROS generation. Finally, the challenges and future research direction of this field are presented. This review is dedicated to unraveling the enigmas surrounding the interplay of nanomedicine and organisms.
基金：
Science and Technology Project of Sichuan Province (24GJHZ0434),
opening competition mechanism to select the best candidates in Affiliated Hospital of North Sichuan Medical College (2022JB009), Key Laboratory of Emergency and Trauma (Hainan Medical University), Ministry of Education (grant.KLET-201907, KLET-202014)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区材料科学
小类|3 区化学：综合3 区材料科学：综合3 区纳米科技3 区物理：应用
最新[2023]版：
大类|3 区材料科学
小类|3 区化学：综合3 区材料科学：综合3 区纳米科技3 区物理：应用
第一作者：
第一作者机构：[1]Department of Ultrasound, Institute of Ultrasound Teaching and Research, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ultrasound, Institute of Ultrasound Teaching and Research, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.[2]Department of Radiology, Institute of Radiation and Therapy, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.[3]Institute of Nanomedicine Innovation Research and Transformation, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
推荐引用方式(GB/T 7714)：
Jiang Lingfeng,Luo Menglin,Wang Jiawei,et al.Advances in antitumor application of ROS enzyme-mimetic catalysts[J].Nanoscale.2024,doi:10.1039/d4nr02026j.
APA：
Jiang Lingfeng,Luo Menglin,Wang Jiawei,Ma Zijun,Zhang Chuan...&Li Ling.(2024).Advances in antitumor application of ROS enzyme-mimetic catalysts.Nanoscale,,
MLA：
Jiang Lingfeng,et al."Advances in antitumor application of ROS enzyme-mimetic catalysts".Nanoscale .(2024)
