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The role of iron overload and ferroptosis in arrhythmia pathogenesis

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机构： [1]Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China. [2]Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.

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关键词： Ferroptosis Molecular mechanism Arrhythmia Oxidative stress Iron overload

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Ferroptosis is a newly discovered form of programmed cell death triggered by intracellular iron overload, which leads to the accumulation of lipid peroxides in various cells. It has been implicated in the pathogenesis and progression of various diseases, including tumors, neurological disorders, and cardiovascular diseases. The intricate mechanism underlying ferroptosis involves an imbalance between the oxidation and antioxidant systems, disturbances in iron metabolism, membrane lipid peroxidation, and dysregulation of amino acid metabolism. We highlight the key molecular mechanisms governing iron overload and ferroptosis, and discuss potential molecular pathways linking ferroptosis with arrhythmias.© 2024 The Authors.

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第一作者机构： [1]Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

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