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Engineered Cell Membrane-Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation

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机构: [1]Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou University Wenzhou 325035, China [2]Key Lab of Biohealth Materials andChemistry ofWenzhou Wenzhou University Wenzhou 325035, China [3]Wenzhou Institute University of Chinese Academy of Sciences Wenzhou 325000, China [4]Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University Chongqing 400044, China [5]Chongqing Engineering Laboratory ofNano/Micro BiologicalMedicine Detection Technology Chongqing University of Science and Technology Chongqing 401331, China [6]Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing 400714, China [7]College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065, China [8]JinFeng Laboratory Chongqing 401329, China [9]Department of Neuro-Oncology ChongqingUniversityCancerHospital Chongqing 400044, China
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关键词: engineered cell membrane-coated nanoparticles glioma immunomodulation strategies targeted drug delivery tumor microenvironment

摘要:
Gliomas, the most prevalent primary brain tumors, pose considerable challenges due to their heterogeneity, intricate tumor microenvironment (TME), and blood-brain barrier (BBB), which restrict the effectiveness of traditional treatments like surgery and chemotherapy. This review provides an overview of engineered cell membrane technologies in glioma therapy, with a specific emphasis on targeted drug delivery and modulation of the immune microenvironment. This study investigates the progress in engineered cell membranes, encompassing physical, chemical, and genetic alterations, to improve drug delivery across the BBB and effectively target gliomas. The examination focuses on the interaction of engineered cell membrane-coated nanoparticles (ECM-NPs) with the TME in gliomas, emphasizing their potential to modulate glioma cell behavior and TME to enhance therapeutic efficacy. The review further explores the involvement of ECM-NPs in immunomodulation techniques, highlighting their impact on immune reactions. While facing obstacles related to membrane stability and manufacturing scalability, the review outlines forthcoming research directions focused on enhancing membrane performance. This review underscores the promise of ECM-NPs in surpassing conventional therapeutic constraints, proposing novel approaches for efficacious glioma treatment.© 2024 Wiley‐VCH GmbH.

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 2 区 工程:生物医学 2 区 材料科学:生物材料 2 区 纳米科技
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 工程:生物医学 2 区 材料科学:生物材料 2 区 纳米科技
第一作者:
第一作者机构: [1]Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou University Wenzhou 325035, China [2]Key Lab of Biohealth Materials andChemistry ofWenzhou Wenzhou University Wenzhou 325035, China
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通讯作者:
通讯机构: [1]Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou University Wenzhou 325035, China [2]Key Lab of Biohealth Materials andChemistry ofWenzhou Wenzhou University Wenzhou 325035, China [4]Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University Chongqing 400044, China [7]College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065, China [8]JinFeng Laboratory Chongqing 401329, China [9]Department of Neuro-Oncology ChongqingUniversityCancerHospital Chongqing 400044, China
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