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Thermal ablation with and without adjuvant systemic therapy: a nationwide multicenter observational cohort study of solitary colorectal liver metastases

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资源类型：
Pubmed体系：
作者：
Li Jianming[1] ; Pang Chuan[1] ; Liu Guangjian[2] ; Xie Xiaoyan[3] ; Zhang De-Zhi[4] ; Li Kai[5] ; Li Zhishuai[6] ; He Guangbin[7] ; Xu Erjiao[8] ; Zhong Huage[9] ; Yang Hong[10] ; Lu Man[11] ; Lou Kexin[12] ; Xie Xiang[13] ; Lan Sirong[14] ; Li Qian[15] ; Dai Guanghai[16] ; Yu Jie[1,*2] ; Liang Ping[1,*1] ;
机构： [1]Department of Interventional Ultrasound, PLA Medical College & 5th Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China, 100853. [2]Department of Medical Ultrasonics, The Sixth Affiliated Hospital of Sun Yat-Sen University, NO.26 Yuan cun er heng Road, Guangzhou, China, 510655. [3]Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, 58# Zhongshan Road 2, Guangzhou, China 510080. [4]Department of Abdominal Ultrasound, The First Affiliated Hospital of Jilin University, NO. 1 of Xinmin street, Chaoyang district, Changchun, China, 130012. [5]Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, China, 510630. [6]Biliary Tract Surgery Department I, Eastern Hepatobiliary Surgery Hospital, Secondary Military Medical University, Shanghai, P. R. China, No. 225 Changhai Road, Shanghai, P. R. China, 200438 [7]Department of Ultrasound, Xijing Hospital, the Fourth Military Medical University, No.127 Changle West Road, Xian, China, 733399 [8]Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, No. 3025, Shennanzhong Road, Shenzhen, 518033, PR China. [9]Guangxi Clinical Research Center for CRC/Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, China, 530021. [10]Department of Ultrasound, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China, 530021. [11]Department of Ultrasound Medicine & Laboratory of Translational Research in Ultrasound Theranostics, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China, Chengdu, 610041. [12]Department of Medical Ultrasound, Xuzhou Central Hospital, No.199 Jiefang South Road Xuzhou, China, 221009 [13]Department of Interventional Ultrasound, The Second Hospital of Anhui Medical University, No. 678 Furong Road, Hefei, China, 230601 [14]Department of Ultrasound, Meizhou People's Hospital, No.63 Huangtang Road, Meizhou, China, 514031 [15]Department of Ultrasound, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China, 450008 [16]Department of Medical Oncology, PLA Medical College & 5th Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China, 100853.
出处：
DOI： 10.1097/JS9.0000000000001397
ISSN：

关键词： Thermal ablation Systemic therapy Liver metastases Colorectal cancer

摘要：
Thermal ablation is routinely used for solitary colorectal liver metastases (SCLM), but the added value of adjuvant systemic therapy in SCLM remains unclear. This study aimed to compare the long-term outcomes for SCLM treated by ablation alone (AB) versus ablation plus systemic therapy (AS).This multicenter retrospective study using nationwide data from fourteen institutions between October 2010 and May 2023, 369 patients with initial SCLM smaller than 5 cm, no extrahepatic metastases, and colorectal cancer R0 resection treated by thermal ablation were included. The crude analysis was used to analyze eligible cases between the two groups. The propensity score matching (PSM) to control for potential confounders in each matched group. Subgroup analyses were performed to identify specific survival benefits.61.2% (226/369) of eligible patients were treated with AS and 38.8% (143/369) with AB. During the median follow-up period of 8.8 years, 1-/3-/5-year DFS/OS rates did not differ between the two groups, when analyzed via PSM (P=0.52/0.08). Subgroup analysis revealed that AS was significantly associated with better OS than AB in patients with plasma CEA >5 ug/L (P=0.036), T (III-IV) category of primary cancer (P=0.034), or clinical risk score (1-2) (P=0.041). In each matched group, we did find a significant difference in drug-related adverse events (P<0.001) between AS group (24.1%, 28/116) and AB group (0.0%, 0/116).For patients with plasma CEA >5 ug/L, T (III-IV) category of primary cancer, or clinical risk score (1-2), thermal ablation plus systemic therapy appeared to be associated with improved overall survival. Thermal ablation was equally effective in disease-free survival for treating solitary colorectal liver metastasis, whether with or without adjuvant systemic therapy.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 外科
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 外科
第一作者：
第一作者机构： [1]Department of Interventional Ultrasound, PLA Medical College & 5th Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China, 100853.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Interventional Ultrasound, PLA Medical College & 5th Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China, 100853. [*1]Department of Interventional Ultrasound, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China, 100039. 28 Fuxing Road, Beijing,100853, China. [*2]Department of Interventional Ultrasound, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China, 100039. 28 Fuxing Road, Beijing,100853, China.
推荐引用方式(GB/T 7714)：
Li Jianming,Pang Chuan,Liu Guangjian,et al.Thermal ablation with and without adjuvant systemic therapy: a nationwide multicenter observational cohort study of solitary colorectal liver metastases[J].International Journal Of Surgery (London, England).2024,doi:10.1097/JS9.0000000000001397.
APA：
Li Jianming,Pang Chuan,Liu Guangjian,Xie Xiaoyan,Zhang De-Zhi...&Liang Ping.(2024).Thermal ablation with and without adjuvant systemic therapy: a nationwide multicenter observational cohort study of solitary colorectal liver metastases.International Journal Of Surgery (London, England),,
MLA：
Li Jianming,et al."Thermal ablation with and without adjuvant systemic therapy: a nationwide multicenter observational cohort study of solitary colorectal liver metastases".International Journal Of Surgery (London, England) .(2024)

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