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Association of pretreatment neutrophil-to-lymphocyte ratio with clinical outcomes in cancer immunotherapy: An evidence synthesis from 30 meta-analyses

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资源类型：
Pubmed体系：
作者：
Wang Haoyu[1] * ; Yang Ruiyuan[1] * ; Liu Dan[1] ; Li Weimin[1,2,3,4,5] ;
机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [2]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [3]Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [4]The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu 610041, Sichuan, China [5]State Key Laboratory of Respiratory Health and Multimorbidity, Chengdu 610041, Sichuan, China
出处：
DOI： 10.1016/j.intimp.2024.111936
ISSN：

关键词： Neutrophil-to-lymphocyte ratio Cancer Immunotherapy Immune checkpoint inhibitors Umbrella review

摘要：
The Neutrophil-to-lymphocyte ratio (NLR) holds relevance in cancer immunotherapy outcomes, yet its validation remains limited. Thus, we conducted an umbrella review to comprehensively assess the association between pretreatment NLR and immunotherapy outcomes, along with evaluating their credibility and strength.Electronic databases, including PubMed, Web of Science, Embase, Scopus, and Cochrane, were systematically searched for eligible systematic reviews and meta-analyses. Quality assessment and evidence grading utilized AMSTAR, GRADE, and additional classification criteria, following PRISMA and PRIOR guidelines.Thirty unique meta-analyses were included, with 24 associations (80%) exhibiting statistical significance. Notably, associations between pretreatment NLR and the prognosis of renal cell carcinoma, hepatocellular carcinoma, melanoma, and non-small cell lung cancer garnered highly suggestive or convincing evidence grading.Elevated pretreatment NLR correlates with poor outcomes in cancer immunotherapy, suggesting its potential as a biomarker for identifying appropriate treatment populations and predicting clinical outcomes. Nevertheless, further validation through prospective cohort studies is warranted.Copyright © 2024 Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China (grant number 92159302), the Science and Technology Project of Sichuan (grant number 2022ZDZX001), and project for disciplines of excellence, West China Hospital, Sichuan University (grant number ZYGD22009) to Weimin Li.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
第一作者：
第一作者机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [2]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [3]Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [4]The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu 610041, Sichuan, China [5]State Key Laboratory of Respiratory Health and Multimorbidity, Chengdu 610041, Sichuan, China
推荐引用方式(GB/T 7714)：
Wang Haoyu,Yang Ruiyuan,Liu Dan,et al.Association of pretreatment neutrophil-to-lymphocyte ratio with clinical outcomes in cancer immunotherapy: An evidence synthesis from 30 meta-analyses[J].International Immunopharmacology.2024,132:111936.doi:10.1016/j.intimp.2024.111936.
APA：
Wang Haoyu,Yang Ruiyuan,Liu Dan&Li Weimin.(2024).Association of pretreatment neutrophil-to-lymphocyte ratio with clinical outcomes in cancer immunotherapy: An evidence synthesis from 30 meta-analyses.International Immunopharmacology,132,
MLA：
Wang Haoyu,et al."Association of pretreatment neutrophil-to-lymphocyte ratio with clinical outcomes in cancer immunotherapy: An evidence synthesis from 30 meta-analyses".International Immunopharmacology 132.(2024):111936

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