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BRAF/MEK-targeted therapy in BRAF ex15 p.T599dup mutation-driven NSCLC: a case report

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机构： [1]Medical Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Centre, Afliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China

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关键词： NSCLC BRAF Non-V600 p T599dup Case report

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BRAF mutations are found in 1-5% of non-small-cell lung cancer (NSCLC), with V600 and non-V600 accounting for approximately 50% each. It has been confirmed that targeted therapy with dabrafenib + trametinib is effective in patients with metastatic NSCLC carrying BRAF V600E mutations. Preclinical studies have shown that dabrafenib + trametinib may also have inhibitory effects on some types of non-V600E mutations, especially some class II BRAF mutations. However, the efficacy of dabrafenib + trametinib on non-V600E mutant NSCLC in clinical practice only exists in some case reports. Here, we report a case of NSCLC patient carrying BRAF ex15 p.T599dup, who showed a clinical response to the combined therapy of dabrafenib + trametinib.© 2024. The Author(s).

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大类 | 3 区医学

小类 | 4 区肿瘤学

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Q3 ONCOLOGY

影响因子： 2.7 最新[2023版] 3.1 最新五年平均 2.7 出版当年[2023版] 0 出版当年五年平均 2.7 出版前一年[2023版]

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第一作者机构： [1]Medical Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Centre, Afliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China

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