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Role of differentiated embryo-chondrocyte expressed gene 2 in immunity

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机构： [1]Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China. [2]Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China. [3]Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

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关键词： DEC2 DEC1 Bhlhe41 immunity immune cells

摘要：

Differentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor immunotherapy, immune system function regulation, and autoimmune diseases. DEC2 enhances Th2 cell differentiation by regulating the IL-2 and IL-4 signaling pathways and mediates the growth of B-1a cells, thereby promoting the occurrence and development of inflammatory responses. In this study, we review the reported roles of DEC2, including the regulation of immune cell differentiation and cytokine production in various cells in humans, and discuss its potential in treating autoimmune diseases and tumors.Copyright © 2024 Li, Ma, Liu, Tang, Zhang, Huo and Zhang.

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大类 | 2 区医学

小类 | 2 区免疫学

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最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 5.7 最新[2023版] 6.8 最新五年平均 5.7 出版当年[2023版] 0 出版当年五年平均 5.7 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China. [2]Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.

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通讯作者：

通讯机构： [1]Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China. [2]Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.

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