机构：[1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China.[2]Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People’s Republic of China.四川省人民医院四川省肿瘤医院[3]Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine University of Electronic Science and Technology of China, Chengdu, People’s Republic of. China.四川省人民医院[4]School of Medicine, Southwest Medical University of China, Luzhou, People’s Republic of China.[5]Department of Radiotherapy, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People’s Republic of China.四川省人民医院四川省肿瘤医院
Interleukin 12 (IL-12) is a heterodimer consisting of 2 subunits, p35 and p40, with unique associations and interacting functions with its family members. IL-12 is one of the most important cytokines regulating the immune system response and is integral to adaptive immunity. IL-12 has shown marked therapeutic potential in a variety of tumor types. This review therefore summarizes the characteristics of IL-12 and its application in tumor treatment, focusing on its antitumor effects in colorectal cancer (CRC) and potential radiosensitization mechanisms. We aim to provide a current reference for IL-12 and other potential CRC treatment strategies.
基金：
Excellent Youth Foundation Project of Sichuan Cancer Hospital [YB2021037]; Sichuan Science Fund for Distinguished Young Scholars [23NSFJQ0104]
第一作者机构：[1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China.
通讯作者：
通讯机构：[4]School of Medicine, Southwest Medical University of China, Luzhou, People’s Republic of China.[5]Department of Radiotherapy, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People’s Republic of China.
推荐引用方式(GB/T 7714)：
Zhu Ziwei,Peng Qian,Duan Xingmei,et al.Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer[J].JOURNAL OF INTERFERON AND CYTOKINE RESEARCH.2024,44(4):158-169.doi:10.1089/jir.2023.0190.
APA：
Zhu, Ziwei,Peng, Qian,Duan, Xingmei&Li, Jie.(2024).Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer.JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,44,(4)
MLA：
Zhu, Ziwei,et al."Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer".JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 44..4(2024):158-169
