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The specialized sesquiterpenoids produced by the genus Elephantopus L.: Chemistry, biological activities and structure-activity relationship exploration

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资源类型：
Pubmed体系：
作者：
Rao Qian-Ru[1,2] ; Rao Jian-Bo[3] ; Zhao Min[1] ;
机构： [1]Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China [2]Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China [3]Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, People’s Republic of China
出处：
DOI： 10.1016/j.phytochem.2024.114041
ISSN：

关键词： Elephantopus L Asteraceae Sesquiterpenoids Biological activity Structure-activity relationship

摘要：
The genus Elephantopus L. is a valuable resource rich in sesquiterpenoids with structural diversity and various bioactivities, showing great potential for applications in medicinal field and biological industry. Up to now, over 129 sesquiterpenoids have been isolated and identified from this plant genus, including 114 germacrane-type, 7 guaianolide-type, 5 eudesmane-type, 1 elemanolide-type, and 2 bis-sesquiterpenoids. These sesquiterpenoids were reported to show a diverse range of pharmacological properties, including cytotoxic, anti-tumor, anti-inflammatory, antimicrobial, and antiprotozoal. Consequently, some of them were identified as active scaffolds in the design and development of drugs. Considering that there is currently no overview available that covers the sesquiterpenoids and their biological activities in the Elephantopus genus, this article aims to comprehensively review the chemical structures, biosynthetic pathways, pharmacological properties, and structure-activity relationship of sesquiterpenoids found in the Elephantopus genus, which will establish a theoretical framework that can guide further research and exploration of sesquiterpenoids from Elephantopus plants as promising therapeutic agents.Copyright © 2024 Elsevier Ltd. All rights reserved.

基金：
The authors express their profound gratitude for the financial support provided by the National Natural Science Foundation of China (82174077 and 81903500) and the Science and Technology Department of Sichuan Province (2023NSFSC1772) for this research
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
第一作者：
第一作者机构： [1]Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China [2]Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China
通讯作者：
推荐引用方式(GB/T 7714)：
Rao Qian-Ru,Rao Jian-Bo,Zhao Min.The specialized sesquiterpenoids produced by the genus Elephantopus L.: Chemistry, biological activities and structure-activity relationship exploration[J].Phytochemistry.2024,221:114041.doi:10.1016/j.phytochem.2024.114041.
APA：
Rao Qian-Ru,Rao Jian-Bo&Zhao Min.(2024).The specialized sesquiterpenoids produced by the genus Elephantopus L.: Chemistry, biological activities and structure-activity relationship exploration.Phytochemistry,221,
MLA：
Rao Qian-Ru,et al."The specialized sesquiterpenoids produced by the genus Elephantopus L.: Chemistry, biological activities and structure-activity relationship exploration".Phytochemistry 221.(2024):114041

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