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Long noncoding RNA H19: functions and mechanisms in regulating programmed cell death in cancer

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机构: [1]Department of Urology, Institute of Urology, West China Hospital, West China School of Medicine, Sichuan University, 610041 Chengdu, China [2]Department of ReproductiveMedicine, West China Second University Hospital of Sichuan University, Chengdu, China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children (SichuanUniversity), Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, China
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Long noncoding RNAs (lncRNAs) are a group of noncoding RNAs with transcript lengths of >200 nucleotides. Mounting evidence suggests that lncRNAs are closely associated with tumorigenesis. LncRNA H19 (H19) was the first lncRNA to function as an oncogene in many malignant tumors. Apart from the established role of H19 in promoting cell growth, proliferation, invasion, migration, epithelial-mesenchymal transition (EMT), and metastasis, it has been recently discovered that H19 also inhibits programmed cell death (PCD) of cancer cells. In this review, we summarize the mechanisms by which H19 regulates PCD in cancer cells through various signaling pathways, molecular mechanisms, and epigenetic modifications. H19 regulates PCD through the Wnt/β-catenin pathway and the PI3K-Akt-mTOR pathway. It also acts as a competitive endogenous RNA (ceRNA) in PCD regulation. The interaction between H19 and RNA-binding proteins (RBP) regulates apoptosis in cancer. Moreover, epigenetic modifications, including DNA and RNA methylation and histone modifications, are also involved in H19-associated PCD regulation. In conclusion, we summarize the role of H19 signaling via PCD in cancer chemoresistance, highlighting the promising research significance of H19 as a therapeutic target. We hope that our study will contribute to a broader understanding of H19 in cancer development and treatment.© 2024. The Author(s).

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出版当年[2023]版:
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版:
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
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第一作者机构: [1]Department of Urology, Institute of Urology, West China Hospital, West China School of Medicine, Sichuan University, 610041 Chengdu, China
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通讯机构: [2]Department of ReproductiveMedicine, West China Second University Hospital of Sichuan University, Chengdu, China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children (SichuanUniversity), Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, China
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