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Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy

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Pubmed体系：

收录情况： ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：领军期刊

作者：
Ye Jing[1] * ; Zhang Jin[1] * ; Zhu Yanghui[1] ; Wang Lian[1,2] ; Jiang Xian[1] ; Liu Bo[1] ; He Gu[1,2] ;
机构： [1]Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. [2]Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease Related Molecular Network, Chengdu 610041, China.
出处：
DOI： 10.1016/j.apsb.2023.08.008
ISSN：

关键词： Beclin-1 PI3KC3 complex Autophagy Non-autophagy Cancer therapy

摘要：
Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 kinase) complex, thus controlling autophagy induction and other cellular trafficking events. Notably, there is mounting evidence establishing the implications of Beclin-1 in diverse tumorigenesis processes, including tumor suppression and progression as well as resistance to cancer therapeutics and CSC (cancer stem-like cell) maintenance. More importantly, Beclin-1 has been confirmed as a potential target for the treatment of multiple cancers. In this review, we provide a comprehensive survey of the structure, functions, and regulations of Beclin-1, and we discuss recent advances in understanding the controversial roles of Beclin-1 in oncology. Moreover, we focus on summarizing the targeted Beclin-1-regulating strategies in cancer therapy, providing novel insights into a promising strategy for regulating Beclin-1 to improve cancer therapeutics in the future.© 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

基金：
This work was supported by the National Natural Science Foundation of China (Grant Nos. 22177084 and 82173666), Sichuan Science and Technology Program (Grant No. 2022YFQ0054, China), and the Open Research Fund of Chengdu University of Traditional Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China.
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 药学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 药学
第一作者：
第一作者机构： [1]Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. [2]Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease Related Molecular Network, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Ye Jing,Zhang Jin,Zhu Yanghui,et al.Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy[J].Acta Pharmaceutica Sinica B.2023,13(12):4688-4714.doi:10.1016/j.apsb.2023.08.008.
APA：
Ye Jing,Zhang Jin,Zhu Yanghui,Wang Lian,Jiang Xian...&He Gu.(2023).Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy.Acta Pharmaceutica Sinica B,13,(12)
MLA：
Ye Jing,et al."Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy".Acta Pharmaceutica Sinica B 13..12(2023):4688-4714

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