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Molecular PET/CT mapping of rhACE2 distribution and quantification in organs to aid in SARS-CoV-2 targeted therapy

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资源类型：
Pubmed体系：
作者：
Wang Zilei[1,2] * ; Zhao Chuanke[3] * ; Li Chuangui[4] * ; Liu Song[2] ; Ding Jin[2] ; He Chengxue[2] ; Liu Jiayue[2] ; Dong Bin[5] ; Yang Zhi[2,6] ; Liu Qi[6,7] ; Zhu Hua[2,6] ; Liu Youping[1] ;
机构： [1]Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, Luzhou, Sichuan, China. [2]State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China. [3]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, China. [4]Department of Nuclear Medicine, First Affiliated Hospital of Hebei North University, Zhangjiakou, China. [5]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Central Laboratory, Peking University Cancer Hospital & Institute, Beijing, China. [6]Department of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China. [7]International Cancer Center, Department of medicine, Shenzhen University, Shenzhen, Guangdong, China.
出处：
DOI： 10.1002/jmv.29221
ISSN：

关键词： 68Ga‐HZ20 PET imaging rhACE2‐organ model SARS‐CoV‐2

摘要：
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, poses a significant threat to public health. Angiotensin-converting enzyme 2 (ACE2) is a key receptor for SARS-CoV-2 infection. Recombinant human ACE2 (RhACE2), as a soluble supplement for human ACE2, can competitively block SARS-CoV-2 infection. In this study, a mouse organ in situ rhACE2 high aggregation model was constructed for the first time, and in vivo real-time positron emission tomography (PET) imaging of rhACE2 in the mouse model was performed using an ACE2-specific agent 68 Ga-HZ20. This radiotracer exhibits reliable radiochemical properties in vitro and maintains a high affinity for rhACE2 in vivo. In terms of probe uptake, 68 Ga-HZ20 showed a good target-to-nontarget ratio and was rapidly cleared from the circulatory system and excreted by the kidneys and urinary system. PET imaging with this radiotracer can noninvasively and accurately monitor the content and distribution of rhACE2 in the body, which clarifies that rhACE2 can aggregate in multiple organs, suggesting the preventive and therapeutic potential of rhACE2 for SARS-CoV-2 and COVID-19.© 2023 Wiley Periodicals LLC.

基金：
The Pilot Project (4th Round) to Reform Public Development of Beijing Municipal Medical Research Institute, Grant/Award Number: 2021‐1; Third foster plan in 2019 “Molecular Imaging Probe Preparation and Characterization of Key Technologies and Equipment”; Shenzhen Science and Technology Innovation Program, Grant/Award Number: 1210318663; Beijing Hospitals Authority Dengfeng Project, Grant/Award Number: DFL20191102
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 病毒学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 病毒学
第一作者：
第一作者机构： [1]Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, Luzhou, Sichuan, China. [2]State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [2]State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China. [6]Department of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, China. [7]International Cancer Center, Department of medicine, Shenzhen University, Shenzhen, Guangdong, China.
推荐引用方式(GB/T 7714)：
Wang Zilei,Zhao Chuanke,Li Chuangui,et al.Molecular PET/CT mapping of rhACE2 distribution and quantification in organs to aid in SARS-CoV-2 targeted therapy[J].Journal of medical virology.2023,95(11):e29221.doi:10.1002/jmv.29221.
APA：
Wang Zilei,Zhao Chuanke,Li Chuangui,Liu Song,Ding Jin...&Liu Youping.(2023).Molecular PET/CT mapping of rhACE2 distribution and quantification in organs to aid in SARS-CoV-2 targeted therapy.Journal of medical virology,95,(11)
MLA：
Wang Zilei,et al."Molecular PET/CT mapping of rhACE2 distribution and quantification in organs to aid in SARS-CoV-2 targeted therapy".Journal of medical virology 95..11(2023):e29221

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