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Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Li Hu[1,2] * ; Gong Huarui[3,4] * ; Wong Tsz Hung[1] * ; Zhou Jingkun[1,5] * ; Wang Yuqiong[2] * ; Lin Long[6] ; Dou Ying[4] ; Jia Huiling[1,5] ; Huang Xingcan[1] ; Gao Zhan[1] ; Shi Rui[1] ; Huang Ya[1,5] ; Chen Zhenlin[1] ; Park Wooyoung[1] ; Li Ji Yu[1,5] ; Chu Hongwei[1] ; Jia Shengxin[1] ; Wu Han[2] ; Wu Mengge[1] ; Liu Yiming[1] ; Li Dengfeng[1] ; Li Jian[1] ; Xu Guoqiang[1] ; Chang Tianrui[2] ; Zhang Binbin[1,5] ; Gao Yuyu[1] ; Su Jingyou[1] ; Bai Hao[7] ; Hu Jie[7] ; Yiu Chun Ki[1,5] ; Xu Chenjie[1] ; Hu Wenchuang[8] ; Huang Jiandong[9,10,11,12] ; Chang Lingqian[13,14] ; Yu Xinge[15,16] ;
机构： [1]Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, 999077, China. [2]Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, 100083, Beijing, China. [3]Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. [4]School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, 999077, China. [5]Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, 999077, China. [6]College of Engineering, Peking University, 100871, Beijing, China. [7]Department of Laboratory Medicine, Med+X Center for Manufacturing, West China Precision Medicine Industrial Technology Institute, Department of Liver Surgery, Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. [8]Department of Laboratory Medicine, Med+X Center for Manufacturing, West China Precision Medicine Industrial Technology Institute, Department of Liver Surgery, Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. [9]Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. [10]School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, 999077, China. [11]Clinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. [12]Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen University, Guangzhou, 510120, China. [13]Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, 100083, Beijing, China. [14]School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, China. [15]Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, 999077, China. [16]Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, 999077, China.
出处：
DOI： 10.1038/s41467-023-43189-z
ISSN：

摘要：
The rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections.© 2023. The Author(s).

基金：
This work was supportted by the National Natural Science Foundation of China (Grants No. 62122002), the City University of Hong Kong (Grants No. 9667221, 9680322 and 9678274), in part of the InnoHK Project on Project 2.2—AI-based 3D ultrasound imaging algorithm at Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE). Prof. L.C. thanks the funding support of National Natural Science Foundation of China (Grants Nos. 32071407 and 62003023), National Key Research and Development Program of China (Grant No. 2022YFB3205600, 2023YFC2415900). Prof. J.H. thanks the funding support of the Government of the Hong Kong Special Administrative Region (COVID1903010, T-11-709/21-N).
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2023]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
JCR分区：
出版当年[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, 999077, China. [2]Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, 100083, Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [9]Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. [10]School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, 999077, China. [11]Clinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. [12]Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen University, Guangzhou, 510120, China. [13]Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, 100083, Beijing, China. [14]School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, China. [15]Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, 999077, China. [16]Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, 999077, China.
推荐引用方式(GB/T 7714)：
Li Hu,Gong Huarui,Wong Tsz Hung,et al.Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation[J].NATURE COMMUNICATIONS.2023,14(1):7539.doi:10.1038/s41467-023-43189-z.
APA：
Li Hu,Gong Huarui,Wong Tsz Hung,Zhou Jingkun,Wang Yuqiong...&Yu Xinge.(2023).Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation.NATURE COMMUNICATIONS,14,(1)
MLA：
Li Hu,et al."Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation".NATURE COMMUNICATIONS 14..1(2023):7539

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