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Personalised neoantigen-based therapy in colorectal cancer

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机构： [1]Department of Biotherapy and Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. [2]Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. [3]The Second Clinical Medical College of Lanzhou University, Lanzhou, China. [4]Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, China. [5]Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, China.

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关键词： cancer vaccine colorectal cancer immunotherapy neoantigens targeted therapy

摘要：

Colorectal cancer (CRC) has become one of the most common tumours with high morbidity, mortality and distinctive evolution mechanism. The neoantigens arising from the somatic mutations have become considerable treatment targets in the management of CRC. As cancer-specific aberrant peptides, neoantigens can trigger the robust host immune response and exert anti-tumour effects while minimising the emergence of adverse events commonly associated with alternative therapeutic regimens. In this review, we summarised the mechanism, generation, identification and prognostic significance of neoantigens, as well as therapeutic strategies challenges of neoantigen-based therapy in CRC. The evidence suggests that the establishment of personalised neoantigen-based therapy holds great promise as an effective treatment approach for patients with CRC.© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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出版当年[2023]版：

大类 | 1 区医学

小类 | 2 区医学：研究与实验 2 区肿瘤学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区医学：研究与实验 2 区肿瘤学

第一作者：

第一作者机构： [1]Department of Biotherapy and Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

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通讯作者：

通讯机构： [1]Department of Biotherapy and Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. [5]Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, China. [*1]Department of Biotherapy and Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. [*2]Clinical Trial Center, West China Hospital, Sichuan University, Chengdu, China.

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