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A multicenter prospective study on the management of hepatoblastoma in children: a report from the Chinese Children's Cancer Group

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收录情况： ◇ SCIE ◇ CSCD-C ◇ 卓越：梯队期刊

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机构： [1]Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China. [2]Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. [3]Department of Hematology/Oncology, Children's Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 41005, China. [4]Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. [5]Department of Hematology/Oncology, Guangzhou Women and Children's Medical Center, National Children's Medical Center for South Central Region, Guangzhou, 510623, China. [6]Department of Hematology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China. [7]Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. [8]Department of Hematology/Oncology, Qilu Children's Hospital of Shandong University, Jinan, 250022, China. [9]Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, 201102, China. [10]Department of General Surgery, Shanghai Children's Medical Center (National Children's Medical Center-Shanghai), Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. [11]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. [12]Department of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China. [13]Department of Hematology/Oncology, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. [14]Department of Hematology/Oncology, Henan Children's Hospital, Zhengzhou, 450018, China. [15]Department of Pediatric General Surgery, Hebei Children's Hospital of Hebei Medical University, Shijiazhuang City, 050031, China. [16]Children's Hospital, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. [17]Department of Paediatric Hematology/Oncology, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China. [18]Department of Paediatric Hematology/Oncology, Dalian Women and Children's Medical Group, Dalian, 116037, China. [19]Department of Pediatric Hematology/Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China. [20]Department of General Surgery, Children's Hospital of Soochow University, Suzhou, 215028, China. [21]Department of Pediatric Surgery, the Second Hospital of HeBei Medical University, Shijiazhuang, 050000, China. [22]Department of Paediatric Hematology/Oncology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. [23]Department of Pediatric Surgery, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. [24]Department of Pediatrics, Xiangya Hospital Central South University, Changsha, 410008, China. [25]Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. [26]Clinical Research and Innovation Unit, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. [27]Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China.

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关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

摘要：

This study aimed to identify survival risk factors in Chinese children with hepatoblastoma (HB) and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group (CCCG) in 2016.A multicenter, prospective study that included 399 patients with HB from January 2015 to June 2020 was conducted. Patient demographics, treatment protocols, and other related information were collected. Cox regression models and Kaplan-Meier curve methods were used.The 4-year event-free survival (EFS) and overall survival (OS) were 76.9 and 93.5%, respectively. The 4-year EFS rates for the very-low-risk, low-risk, intermediate-risk, and high-risk groups were 100%, 91.6%, 81.7%, and 51.0%, respectively. The 4-year OS was 100%, 97.3%, 94.4%, and 86.8%, respectively. Cox regression analysis found that age, tumor rupture (R +), and extrahepatic tumor extension (E +) were independent prognostic factors. A total of 299 patients had complete remission, and 19 relapsed. Patients with declining alpha-fetoprotein (AFP) > 75% after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those ≤ 75%.The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 therapy. Age ≥ 8 years, R + , and E + were independent risk factors for prognosis. Patients with a declining AFP > 75% after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.© 2023. The Author(s).

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大类 | 2 区医学

小类 | 3 区儿科

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Q1 PEDIATRICS

影响因子： 3.6 最新[2023版] 4.2 最新五年平均 3.6 出版当年[2023版] 0 出版当年五年平均 3.6 出版前一年[2023版]

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第一作者机构： [1]Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665, Kongjiang Road, Yangpu District, Shanghai, 200092, China.

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A multicenter prospective study on the management of hepatoblastoma in children: a report from the Chinese Children's Cancer Group

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