机构：[1]Department of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China.四川大学华西医院[2]Institute of Urology, West China Hospital of Sichuan University, Chengdu 610041, China.四川大学华西医院
Selenium, a trace mineral with various biological functions, has become a focal point in prostate cancer research. This review aims to present a comprehensive overview of selenium's involvement in prostate cancer, covering its impact on prevention, development, treatment, and underlying mechanisms. Observational studies have revealed a link between selenium levels and selenoproteins with prostate cancer progression. However, randomized controlled studies have shown that selenium supplementation does not prevent prostate cancer (HR: 0.95; 95% CI 0.80-1.13). This discrepancy might be attributed to selenoprotein single nucleotide polymorphisms. In the context of combinatorial therapy, selenium has demonstrated promising synergistic potential in the treatment of prostate cancer. Emerging evidence highlights the significant role of selenium and selenoproteins in prostate cancer, encompassing AR signaling, antioxidative properties, cell death, cell cycle regulation, angiogenesis, epigenetic regulation, immunoregulation, epithelial-mesenchymal transformation, and redox signal. In conclusion, selenium's diverse properties make it a promising trace mineral in prostate cancer prevention, development, and treatment and as a platform for exploring novel agents.
基金：
This work was supported by the National Natural Science Foundation of China (Grant
Number 81974098, 82000721, 82170784, 82102778) and Sichuan Science and Technology Program
(Grant Number 2020YFS0068).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|3 区药物化学3 区药学
最新[2023]版：
大类|3 区医学
小类|3 区药物化学3 区药学
第一作者：
第一作者机构：[1]Department of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China.[2]Institute of Urology, West China Hospital of Sichuan University, Chengdu 610041, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China.[2]Institute of Urology, West China Hospital of Sichuan University, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Jiang Jinjiang,Chen Bo,Tang Bo,et al.Selenium in Prostate Cancer: Prevention, Progression, and Treatment[J].Pharmaceuticals (Basel, Switzerland).2023,16(9):doi:10.3390/ph16091250.
APA：
Jiang Jinjiang,Chen Bo,Tang Bo&Wei Qiang.(2023).Selenium in Prostate Cancer: Prevention, Progression, and Treatment.Pharmaceuticals (Basel, Switzerland),16,(9)
MLA：
Jiang Jinjiang,et al."Selenium in Prostate Cancer: Prevention, Progression, and Treatment".Pharmaceuticals (Basel, Switzerland) 16..9(2023)
