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Predicting cutaneous malignant melanoma patients' survival using deep learning: a retrospective cohort study

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机构: [1]Dermatology Department, General Hospital of Western Theater Command PLA, No. 270, Rongdu Avenue, Chengdu 610083, Sichuan, China [2]Cancer Research Center, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, No. 9 Beiguan Street, Tongzhou District, Beijing 101149, China [3]Department of Respiratory and Critical Care Medicine, General Hospital of Western Theater Command, No. 270 Rongdu Avenue, Chengdu 610083, Sichuan, China [4]Dermatology Department, Medical Center Hospital of Qionglai City, No. 172 Xinglin Road, Qionglai City, Chengdu 611500, Sichuan, China
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Cutaneous malignant melanoma (CMM) has the worst prognosis among skin cancers, especially metastatic CMM. Predicting its prognosis accurately could direct clinical decisions.The Surveillance, Epidemiology, and End Results database was screened to collect CMM patients' data. According to diagnosed time, patients were subdivided into three cohorts, train cohort (diagnosed between 2010 and 2013), validation cohort (diagnosed in 2014), and test cohort (diagnosed in 2015). Train cohort was used to train deep learning survival model for cutaneous malignant melanoma (DeepCMM). DeepCMM was then evaluated in train cohort and validation cohort internally, and validated in test cohort externally.DeepCMM showed 0.8270 (95% CI, confidence interval, CI 0.8260-0.8280) as area under the receiver operating characteristic curve (AUC) in train cohort, 0.8274 (95% CI 0.8286-0.8298) AUC in validation cohort, and 0.8303 (95% CI 0.8289-0.8316) AUC in test cohort. Then DeepCMM was packaged into a Windows 64-bit software for doctors to use.Deep learning survival model for cutaneous malignant melanoma (DeepCMM) can offer a reliable prediction on cutaneous malignant melanoma patients' overall survival.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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出版当年[2023]版:
大类 | 3 区 医学
小类 | 4 区 肿瘤学
最新[2023]版:
大类 | 3 区 医学
小类 | 4 区 肿瘤学
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第一作者机构: [1]Dermatology Department, General Hospital of Western Theater Command PLA, No. 270, Rongdu Avenue, Chengdu 610083, Sichuan, China
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