详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Reprogramming of Treg cells in the inflammatory microenvironment during immunotherapy: a literature review

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Earth Sciences, Kunming University of Science and Technology, Kunming, China. [2]College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. [3]Department of Oncology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China. [4]School of Medicine, Macau University of Science and Technology, Macau, Macau SAR, China. [5]Institute of Medical Information/Library, Chinese Academy of Medical Sciences, Beijing, China. [6]School of Public Health, Nanchang University, Qianhu, Nanchang, China. [7]Undergraduate Department, Taishan University, Taian, China.

出处：

DOI：

摘要：

Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in the research of tumor progression. Treg cells have the function of inhibiting the immune effector cells, preventing tissue damage, and suppressing inflammation. Under the stimulation of the tumor inflammatory microenvironment (IM), the reprogramming of Treg cells enhances their suppression of immune responses, ultimately promoting tumor immune escape or tumor progression. Reducing the number of Treg cells in the IM or lowering the activity of Treg cells while preventing their reprogramming, can help promote the body's anti-tumor immune responses. This review introduces a reprogramming mechanism of Treg cells in the IM; and discusses the regulation of Treg cells on tumor progression. The control of Treg cells and the response to Treg inflammatory reprogramming in tumor immunotherapy are analyzed and countermeasures are proposed. This work will provide a foundation for downregulating the immunosuppressive role of Treg in the inflammatory environment in future tumor immunotherapy.Copyright © 2023 Wu, Zhou, Cao, Chen, Gong, Zhang, Qiang, Lu and Cao.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

第一作者：

第一作者机构： [1]Department of Earth Sciences, Kunming University of Science and Technology, Kunming, China. [2]College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Earth Sciences, Kunming University of Science and Technology, Kunming, China. [4]School of Medicine, Macau University of Science and Technology, Macau, Macau SAR, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：