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Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Xue Kaizhong[1] ; Gao Bo[2,3] ; Chen Feng[4] ; Wang Meiyun[5] ; Cheng Jingliang[6] ; Zhang Bing[7] ; Zhu Wenzhen[8] ; Qiu Shijun[9] ; Geng Zuojun[10] ; Zhang Xiaochu[11] ; Cui Guangbin[12] ; Yu Yongqiang[13] ; Zhang Quan[14] ; Liao Weihua[15,16,17] ; Zhang Hui[18] ; Xu Xiaojun[19] ; Han Tong[20] ; Qin Wen[1] ; Liu Feng[1] ; Liang Meng[21] ; Guo Lining[1] ; Xu Qiang[1] ; Xu Jiayuan[1] ; Fu Jilian[1] ; Zhang Peng[22] ; Li Wei[22] ; Shi Dapeng[5] ; Wang Caihong[6] ; Lui Su[23] ; Yan Zhihan[24] ; Zhang Jing[25,26] ; Li Jiance[27] ; Wang Dawei[28] ; Xian Junfang[29] ; Xu Kai[30] ; Zuo Xi-Nian[31,32] ; Zhang Longjiang[33] ; Ye Zhaoxiang[22] ; Banaschewski Tobias[34] ; Barker Gareth J[35] ; Bokde Arun L W[36] ; res Sylvane[37] ; Flor Herta[38,39] ; Grigis Antoine[40] ; Garavan Hugh[41] ; Gowland Penny[42] ; Heinz Andreas[43] ; Rüdiger Brühl [44] ; Jean-Luc Martinot[45] ; Marie-Laure Paillère Martinot[45,46] ; Eric Artiges[45,47] ; Frauke Nees[34,38,48] ; Dimitri Papadopoulos Orfanos [40] ; Herve Lemaitre[40] ; Luise Poustka[50] ; Sarah Hohmann[51] ; Nathalie Holz[34] ; Juliane H. Fröhner[52] ; Michael N. Smolka [52] ; Nilakshi Vaidya[53] ; Henrik Walter[43] ; Robert Whelan[54] ; Wen Shen[55] ; Yanwei Miao[56] ; Chunshui Yu[1,57] ;
机构： [1]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China. [2]Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China. [3]Department of Radiology, Yantai Yuhuangding Hospital, Yantai 264000, China. [4]Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, China. [5]Department of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s Hospital, Zhengzhou 450003, China. [6]Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. [7]Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China. [8]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. [9]Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. [10]Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China. [11]Division of Life Science and Medicine, University of Science & Technology of China, Hefei 230027, China. [12]Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi’an 710038, China. [13]Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. [14]Department of Radiology, Characteristic Medical Center of Chinese People’s Armed Police Force, Tianjin 300162, China. [15]Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China. [16]Molecular Imaging Research Center of Central South University, Changsha 410008, China. [17]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China. [18]Department of Radiology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China. [19]Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, China. [20]Department of Radiology, Tianjin Huanhu Hospital, Tianjin 300350, China. [21]School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin 300203, China. [22]Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. [23]Department of Radiology, the Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu 610041, China. [24]Department of Radiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China. [25]Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730030, China. [26]Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou 730030, China. [27]Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. [28]Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China. [29]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. [30]Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China. [31]IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China. [32]Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. [33]Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. [34]Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany. [35]Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom. [36]Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. [37]Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London, London, United Kingdom. [38]Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany. [39]Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany. [40]NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur- Yvette, France. [41]Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05405, USA. [42]Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom. [43]Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. [44]Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany. [45]Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 “Trajectoires développementales & psychiatrie”, University Paris-Saclay, CNRS.Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France. [46]AP-HP. Sorbonne University, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France. [47]Psychiatry Department, EPS Barthélémy Durand, Etampes, France. [48]Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany. [49]Institut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA, Université de Bordeaux, 33076 Bordeaux, France. [50]Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold- Str. 5, 37075 Göttingen, Germany. [51]Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [52]Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany. [53]Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Berlin, Germany. [54]School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland. [55]Department of Radiology, Tianjin First Center Hospital, Tianjin 300192, China. [56]Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. [57]CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
出处：
DOI： 10.1038/s41380-023-02261-2
ISSN：

摘要：
Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear. In 4297 healthy participants (aged 18-30 years), we combined sparse multiple canonical correlation analysis with independent component analysis to identify the three-way covariation patterns of 59 preadult environmental exposures, 760 adult brain imaging phenotypes, and five personality traits, and found two robust environment-brain-personality covariation models with sex specificity. One model linked greater stress and less support to weaker functional connectivity and activity in the default mode network, stronger activity in subcortical nuclei, greater thickness and volume in the occipital, parietal and temporal cortices, and lower agreeableness, consciousness and extraversion as well as higher neuroticism. The other model linked higher urbanicity and better socioeconomic status to stronger functional connectivity and activity in the sensorimotor network, smaller volume and surface area and weaker functional connectivity and activity in the medial prefrontal cortex, lower white matter integrity, and higher openness to experience. We also conducted mediation analyses to explore the potential bidirectional mediation relationships between adult brain imaging phenotypes and personality traits with the influence of preadult environmental exposures and found both environment-brain-personality and environment-personality-brain pathways. We finally performed moderated mediation analyses to test the potential interactions between macro- and microenvironmental exposures and found that one category of exposure moderated the mediation pathways of another category of exposure. These results improve our understanding of the effects of preadult environmental exposures on the adult brain and personality traits and may facilitate the design of targeted interventions to improve mental health by reducing the impact of adverse environmental exposures.© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

基金：
This work was funded by Natural Science Foundation of China (82030053), Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-001A) and Tsinghua- Toyota Joint Research Fund.
语种：
外文
被引次数：
WOS：
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 神经科学 1 区 精神病学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 神经科学 1 区 精神病学
JCR分区：
出版当年[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 NEUROSCIENCES Q1 PSYCHIATRY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 NEUROSCIENCES Q1 PSYCHIATRY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
通讯作者：
通讯机构： [1]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China. [57]CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
推荐引用方式(GB/T 7714)：
Xue Kaizhong,Gao Bo,Chen Feng,et al.Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits[J].MOLECULAR PSYCHIATRY.2023,28(11):4853-4866.doi:10.1038/s41380-023-02261-2.
APA：
Xue Kaizhong,Gao Bo,Chen Feng,Wang Meiyun,Cheng Jingliang...&Chunshui Yu.(2023).Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits.MOLECULAR PSYCHIATRY,28,(11)
MLA：
Xue Kaizhong,et al."Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits".MOLECULAR PSYCHIATRY 28..11(2023):4853-4866

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